Results 61 to 70 of about 1,003,870 (312)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]

, 2015
background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S., Bottcher, R., Dulla, K., Henderson, D. J. P., Hoffmann, R., Houslay, M. D., Jenster, G., Lehman, M. L., Merkle, D., Tevz, G., van Leenders, G. J. L. H., van Strijp, D., Waanders, L. F.   +12 more
core   +1 more source

iFUSE: integrated fusion gene explorer [PDF]

Bioinformatics, 2013
Abstract Summary: We present iFUSE (integrated fusion gene explorer), an online visualization tool that provides a fast and informative view of structural variation data and prioritizes those breaks likely representing fusion genes. This application uses calculated break points to determine fusion genes based on the latest annotation for
Hiltemann, S, McClellan, EA, van Nijnatten, J, Horsman, S (Sebastiaan), Palli, I, Teles Alves, Ines, Hartjes, T, Trapman, Jan, van der Spek, Peter, Jenster, Guido, Stubbs, Andrew   +10 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Current treatment and novel insights regarding ROS1‐targeted therapy in malignant tumors

Cancer Medicine
Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the tyrosine kinase/insulin receptor family. ROS1 facilitates the progression of various malignancies via self‐mutations or rearrangements.
Shizhe Li, He Zhang, Ting Chen, Xiaowen Zhang, Guanning Shang   +4 more
doaj   +1 more source

The fusion landscape of hepatocellular carcinoma

Molecular Oncology, 2019
Most cases of hepatocellular carcinoma (HCC) are already advanced at the time of diagnosis, which limits treatment options. Challenges in early‐stage diagnosis may be due to the genetic complexity of HCC.
Chengpei Zhu, Liangcai Wu, Yanling Lv, Jinxia Guan, Xue Bai, Jianzhen Lin, Tingting Liu, Xiaobo Yang, Simon C. Robson, Xinting Sang, Chenghai Xue, Haitao Zhao   +11 more
doaj   +1 more source

Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia

Frontiers in Oncology, 2017
In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.
Valentina Tosato, Valentina Tosato, Valentina Tosato, Nicole West, Jan Zrimec, Dmitri V. Nikitin, Giannino Del Sal, Roberto Marano, Michael Breitenbach, Carlo V. Bruschi, Carlo V. Bruschi   +10 more
doaj   +1 more source

Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]

, 1993
Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pediatric Cutaneous Anaplastic Lymphoma Kinase-Positive Histiocytosis with DCTN1::ALK Fusion: A Case Report and Literature Search

Diagnostics
Background and Clinical Significance: Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a relatively novel entity, affecting single or multiple organ systems; it is characterized by aggregates of neoplastic cells of the histiocytic lineage ...
Kristóf Levente Korpás, Attila Mokánszki, Lívia Beke, Gábor Méhes, Yi-Che Chang Chien   +4 more
doaj   +1 more source