Results 181 to 190 of about 663,508 (269)

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Systematic approach for dissecting promoters and designing transform systems in microalgae. [PDF]

Microb Cell Fact
Gan Q, Yu X, Jiang X, Huang X, Xin Y, Lu Y.   +5 more
europepmc   +1 more source

Optimizing Cost-Effective gene expression phenotyping approaches in cattle using 3' mRNA sequencing. [PDF]

BMC Genomics
Mohamed RI, Ault-Seay TB, Moisá SJ, Beever JE, Ríus AG, Rowan TN.   +5 more
europepmc   +1 more source

A Microfluidic Multiplex Sorter for Strain Development

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A new multiplex method for high‐throughput screening of yeast strains based on glucoamylase production is presented. Droplets containing single mutant yeast cells are incubated for enzyme production. A sorting platform divides mutants by their high‐ and mid‐activity levels.
Chiara Leal‐Alves, Sebastien Dumont, Zhiyang Deng, Sarah Alkhaldi, Ziuwin Leung, Michelle Oeser, Steve C. C. Shih   +6 more
wiley   +1 more source

New Efficient D‐π‐A and A‐π‐A Structured Type I Radical Photoinitiators for Additive Manufacturing Nanomaterials Preparation

Advanced Materials Technologies, EarlyView.
Groundbreaking advancements are discovered in 3D printing with new type‐I radical photoinitiators, including 1,1‐dimethoxy‐1‐phenylpropan‐2‐one. These innovative compounds, effective under visible light, enhance photopolymerization of acrylates and methacrylates, facilitating the creation of efficient nanocomposites and unlock the future of polymer ...
Andrzej Świeży, Filip Petko, Dominika Krok‐Janiszewska, Patryk Szymaszek, Mariusz Galek, Joanna Ortyl   +5 more
wiley   +1 more source

Embryonic thermal environments drive plasticity in gene expression. [PDF]

Fish Physiol Biochem
Snead AA, Quackenbush CR, Trojahn S, McDonald AL, Lins LSF, Cornelius C, Adams PE, Ma D, Hsu Y, Haag E, Silvestre F, Kanamori A, Earley RL, Kelley JL.   +13 more
europepmc   +1 more source

Optimizing Metamaterial Inverse Design with 3D Conditional Diffusion Model and Data Augmentation

Advanced Materials Technologies, EarlyView.
A generative AI model, the 3D conditional diffusion model (3D‐CDM), is introduced to enhance the inverse design of voxel‐based metamaterials. A data augmentation technique based on topological perturbation expands the dataset, further improving generation quality and accuracy.
Xiaoyang Zheng, Junichiro Shiomi, Takayuki Yamada   +2 more
wiley   +1 more source

The genetic interaction map of the human solute carrier superfamily. [PDF]

Mol Syst Biol
Wolf G, Leippe P, Onstein S, Goldmann U, Frommelt F, Teoh ST, Girardi E, Wiedmer T, Superti-Furga G.   +8 more
europepmc   +1 more source

The Role of Theoretical Calculations for INVEST Systems: Complementarity Between Theory and Experiments and Rationalization of the Results

Advanced Optical Materials, EarlyView.
Theoretical lessons are key for molecules presenting an inverted singlet‐triplet excited state (e.g. S1 and T1) energy difference. This perspective provides a snapshot of the role played by calculations in last years, not only to anticipate experimental findings but also for driving high‐throughput virtual screenings, as well as the main challenge to ...
Ángel José Pérez‐Jiménez, Yoann Olivier, Juan Carlos Sancho‐García   +2 more
wiley   +1 more source