Results 1 to 10 of about 268,817 (310)

Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones [PDF]

, 2017
In B-cell precursor acute lymphoblastic leukemia, the initial leukemic cells share the same antigen receptor gene rearrangements. However, due to ongoing rearrangement processes, leukemic cells with different gene rearrangement patterns can develop ...
Dongen, J.J.M. (Jacques) van, Faham, M. (Malek), Stubbs, A.P. (Andrew), Theunissen, P.M.J. (Prisca), Velden, V.H.J. (Vincent) van der, Zessen, D. (David) van, Zwaan, C.M. (Michel)   +6 more
core   +4 more sources

Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP

Haematologica, 2010
Background BCL6 gene rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma, a malignancy characterized by genetic heterogeneity and wide variability in clinical outcome.
Jesse Shustik, Guangming Han, Pedro Farinha, Nathalie A. Johnson, Susana Ben Neriah, Joseph M. Connors, Laurie H. Sehn, Douglas E. Horsman, Randy D. Gascoyne, Christian Steidl   +9 more
doaj   +1 more source

Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis

Diagnostic Pathology, 2023
Background Epithelioid and spindle rhabdomyosarcoma (ES-RMS) with TFCP2 rearrangement is a recently discovered rare variant of rhabdomyosarcoma composed of epithelioid and spindle cells, because it shows extraordinarily adverse prognosis and is easily ...
Yuan Li, Dan Li, Jingyu Wang, Jinlong Tang   +3 more
doaj   +1 more source

Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]

, 2017
INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela, DE ANGELIS, Federico, DI ROCCO, Alice, Foa, Roberto, Martelli, Maurizio   +4 more
core   +1 more source

The zero exemplar distance problem [PDF]

, 2010
Given two genomes with duplicate genes, \textsc{Zero Exemplar Distance} is the problem of deciding whether the two genomes can be reduced to the same genome without duplicate genes by deleting all but one copy of each gene in each genome.
D. Sankoff, G. Blin, J.E. Hopcroft, M.R. Garey, P. Bonizzoni, R.G. Downey, S. Angibaud, S.S. Adi, V. Ferretti, Z. Chen, Z. Chen   +10 more
core   +1 more source

Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Scientific Reports, 2022
Vertebrate mitochondrial genomes have been extensively studied for genetic and evolutionary purposes, these are normally believed to be extremely conserved, however, different cases of gene rearrangements have been reported.
Paula Montaña-Lozano, Manuela Moreno-Carmona, Mauricio Ochoa-Capera, Natalia S. Medina, Jeffrey L. Boore, Carlos F. Prada   +5 more
doaj   +1 more source

Analysis of Clonal Rearrangement Characteristics and Clinical Application Value of IGH in B-cell Non-Hodgkin’s Lymphoma by Next-generation Sequencing

Zhongliu Fangzhi Yanjiu
Objective To investigate the clonal rearrangement characteristics and clinical application value of IGH gene in B-cell non-Hodgkin’s lymphoma (B-NHL). Methods Demographic and clinical data as well as IGH sequencing results of 55 patients with B-NHL who ...
MA Qiang, ZOU Dongmei, GUO Yixian, ZHAO Hong, CHANG Xiaoli, HU Ronghua, SUN Wanling   +6 more
doaj   +1 more source

MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas [PDF]

, 2006
In view of the certain anatomic site-dependent frequency of chromosomal translocations involved in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were ...
Isaacson PG, Harris NL, Carbone A, Banham A, Streubel B, Ventura RA, Remstein ED, Baens M, Ye H   +8 more
core   +1 more source

T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]

PLoS ONE, 2014
Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma, Rosa Berga-Bolaños, Jyoti Misra Sen   +2 more
doaj   +1 more source

Impact of observational incompleteness on the structural properties of protein interaction networks

, 2006
The observed structure of protein interaction networks is corrupted by many false positive/negative links. This observational incompleteness is abstracted as random link removal and a specific, experimentally motivated (spoke) link rearrangement.
Albert, Alfarano, Bader, Bader, Berg, Breitkreutz, Dall’Asta, Deane, Eisenberg, Gavin, Ho, Ingmar Glauche, Ispolatov, Ispolatov, Lee, Martin Greiner, Mathias Kuhnt, Mering, Milo, Newman, Przulj, Salwinski, Scholz, Sole, Tong, Vazquez, Vazquez, Zanzoni, Ziv   +28 more
core   +1 more source