Results 11 to 20 of about 150,131 (316)

Lack of ROS1 Gene Rearrangement in Glioblastoma Multiforme. [PDF]

PLoS ONE, 2015
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, and the prognosis remains poor. Rearrangement of ROS1 gene, which was shown to have an oncogenic potential, was previously discovered in GBM cell lines.
Sun Min Lim, Junjeong Choi, Jong Hee Chang, Jinyoung Sohn, Kristine Jacobson, Frank Policht, John Schulz, Byoung Chul Cho, Se Hoon Kim   +8 more
doaj   +1 more source

Prevalence and Clinical Impact of Concomitant Mutations in Anaplastic Lymphoma Kinase Rearrangement Advanced Non-small-Cell Lung Cancer (Guangdong Association of Thoracic Oncology Study 1055)

Frontiers in Oncology, 2020
Background: In patients with anaplastic lymphoma kinase (ALK) rearrangement-positive advanced non–small-cell lung cancer (NSCLC), ALK inhibitors are now the standard treatment, but their clinical efficacy varies widely for each patient.
Meichen Li, Xue Hou, Chengzhi Zhou, Weineng Feng, Guanming Jiang, Hao Long, Shuang Yang, Jing Chen, Na Wang, Kaicheng Wang, Likun Chen   +10 more
doaj   +1 more source

Insights into the Evolution of Aphid Mitogenome Features from New Data and Comparative Analysis

Animals, 2022
The complete mitochondrial genomes and their rearrangement patterns can provide useful information for inferring evolutionary history of organisms. Aphids are one of the insect groups with some unique mitogenome features.
Hui Zhang, Congcong Lu, Qian Liu, Tianmin Zou, Gexia Qiao, Xiaolei Huang   +5 more
doaj   +1 more source

ERG rearrangement is associated with prostate cancer-related death in Chinese prostate cancer patients. [PDF]

PLoS ONE, 2014
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management.
Mei Qi, Xiaoqing Yang, Fan Zhang, Tao Lin, Xiubin Sun, Yanjiang Li, Huiqing Yuan, Yubo Ren, Juan Zhang, Xiaomin Qin, Bo Han   +10 more
doaj   +1 more source

A method for computing an inventory of metazoan mitochondrial gene order rearrangements

BMC Bioinformatics, 2011
Background Changes in the order of mitochondrial genes are a good source of information for phylogenetic investigations. Phylogenetic hypotheses are often supported by parsimonious mitochondrial gene order rearrangement scenarios. CREx is a heuristic for
Middendorf Martin, Bernt Matthias
doaj   +1 more source

BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia

Blood Advances, 2016
: We report here on a case of ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia (B-ALL) that has acquired a BCR-ABL1 gene rearrangement as a subclonal change.
Karen A. Dun, Rob Vanhaeften, Tracey J. Batt, Louise A. Riley, Giuseppe Diano, Jan Williamson   +5 more
doaj   +1 more source

The Prevalence of the EML4-ALK Fusion Gene in Cytology Specimens from Patients with Lung Adenocarcinoma

Pulmonary Medicine, 2020
Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed.
Didik S. Heriyanto, Ika Trisnawati, Evan G. Kumara, Vincent Laiman, Fara S. Yuliani, Auliya S. B. Sumpono, Rita Cempaka, Marcellus, Eko Budiono   +8 more
doaj   +1 more source

First Report on Mitochondrial Gene Rearrangement in Non-Biting Midges, Revealing a Synapomorphy in Stenochironomus Kieffer (Diptera: Chironomidae)

Insects, 2022
(1) Background: Gene rearrangement of mitochondrial genome, especially those with phylogenetic signals, has long fascinated evolutionary biologists. The synapomorphic gene rearrangements have been identified across multiple orders and at many different ...
Chen-Guang Zheng, Zheng Liu, Yan-Min Zhao, Yang Wang, Wen-Jun Bu, Xin-Hua Wang, Xiao-Long Lin   +6 more
doaj   +1 more source

Programmed Gene Rearrangements Altering Gene Expression

Science, 1987
Programmed gene rearrangements are used in nature to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens).
Borst, P, Greaves, D
openaire   +3 more sources

Case Report: Patient With Lung Adenocarcinoma With ALK-HLA-DRB1 Rearrangement Shows Impressive Progression-Free Survival After Sequential Crizotinib and Ceritinib Treatment

Frontiers in Oncology, 2022
The anaplastic lymphoma kinase (ALK) gene rearrangement is a driving mutation that underlies about 5-6% of non-small cell lung cancer (NSCLC) cases. Lung cancers that are ALK gene rearrangement-positive can be effectively treated with ALK inhibitors ...
Peng Gao, Kangning Tang, Yuqiu Hao, Wei Li, Xuejiao Lv, Dapeng Li, Yuxi Jia   +6 more
doaj   +1 more source