Results 21 to 30 of about 6,798,395 (302)
Frontiers in Oncology, 2020 Background: In patients with anaplastic lymphoma kinase (ALK) rearrangement-positive advanced non–small-cell lung cancer (NSCLC), ALK inhibitors are now the standard treatment, but their clinical efficacy varies widely for each patient.
Meichen Li +10 more
doaj +1 more source
ERG rearrangement is associated with prostate cancer-related death in Chinese prostate cancer patients. [PDF]
PLoS ONE, 2014 Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management.
Mei Qi +10 more
doaj +1 more source
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription [PDF]
, 1991 Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to ...
Baltimore, David +2 more
core +5 more sources
Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]
, 2000 At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Braun, S. +5 more
core +1 more source
progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss and Rearrangement
PLoS ONE, 2010 Background Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
A. Darling, B. Mau, N. Perna
semanticscholar +1 more source
A method for computing an inventory of metazoan mitochondrial gene order rearrangements
BMC Bioinformatics, 2011 Background Changes in the order of mitochondrial genes are a good source of information for phylogenetic investigations. Phylogenetic hypotheses are often supported by parsimonious mitochondrial gene order rearrangement scenarios. CREx is a heuristic for
Middendorf Martin, Bernt Matthias
doaj +1 more source
Lateral gene transfer, rearrangement, reconciliation [PDF]
BMC Bioinformatics, 2013 Models of ancestral gene order reconstruction have progressively integrated different evolutionary patterns and processes such as unequal gene content, gene duplications, and implicitly sequence evolution via reconciled gene trees. These models have so far ignored lateral gene transfer, even though in unicellular organisms it can have an important ...
Gergely J. Szöllősi +7 more
openaire +6 more sources
On Weighting Schemes for Gene Order Analysis [PDF]
, 2013 Gene order analysis aims at extracting phylogenetic information from the comparison of the order and orientation of the genes on the genomes of different species. This can be achieved by computing parsimonious rearrangement scenarios, i.e. to determine a
Bernt, Matthias +2 more
core +1 more source
Frontiers in Oncology, 2022 The anaplastic lymphoma kinase (ALK) gene rearrangement is a driving mutation that underlies about 5-6% of non-small cell lung cancer (NSCLC) cases. Lung cancers that are ALK gene rearrangement-positive can be effectively treated with ALK inhibitors ...
Peng Gao +6 more
doaj +1 more source
Pulmonary Medicine, 2020 Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed.
Didik S. Heriyanto +8 more
doaj +1 more source