Results 31 to 40 of about 12,124,124 (398)
Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning
Nature Genetics, 2020 The relationship between chromatin organization and gene regulation remains unclear. While disruption of chromatin domains and domain boundaries can lead to misexpression of developmental genes, acute depletion of regulators of genome organization has a ...
Elizabeth Ing-Simmons +5 more
semanticscholar +1 more source
Mathematical approaches to differentiation and gene regulation [PDF]
, 2005 We consider some mathematical issues raised by the modelling of gene networks. The expression of genes is governed by a complex set of regulations, which is often described symbolically by interaction graphs. Once such a graph has been established, there
Soulé, C.
core +3 more sources
Tumor suppressor p53: from engaging DNA to target gene regulation
Nucleic Acids Research, 2020 The p53 transcription factor confers its potent tumor suppressor functions primarily through the regulation of a large network of target genes. The recent explosion of next generation sequencing protocols has enabled the study of the p53 gene regulatory ...
Morgan A. Sammons +3 more
semanticscholar +1 more source
PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription
Cell Reports, 2013 Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer +6 more
doaj +1 more source
Gene Regulation in and out of Equilibrium.
Annual Review of Biophysics, 2020 Determining whether and how a gene is transcribed are two of the central processes of life. The conceptual basis for understanding such gene regulation arose from pioneering biophysical studies in eubacteria.
Felix Wong, J. Gunawardena
semanticscholar +1 more source
Co-Regulated Genes and Gene Clusters [PDF]
Genes, 2021 There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with
Sergey V. Razin +3 more
openaire +2 more sources
Mechanical determinants of chromatin topology and gene expression
Nucleus, 2022 The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha +2 more
doaj +1 more source
Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways. [PDF]
, 2014 Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related ...
Attardo, Geoffrey M +3 more
core +2 more sources
Combinatorial Gene Regulation Using Auto-Regulation
PLoS Computational Biology, 2010 As many as 59% of the transcription factors in Escherichia coli regulate the transcription rate of their own genes. This suggests that auto-regulation has one or more important functions. Here, one possible function is studied. Often the transcription rate of an auto-regulator is also controlled by additional transcription factors.
R. Hermsen (Rutger) +2 more
openaire +5 more sources
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Nature Communications, 2018 The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu +11 more
doaj +1 more source