Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation
, 2016 Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression.
Bose, Indrani +2 more
core +1 more source
miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]
, 2019 open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J. +8 more
core +1 more source
TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance
Nature Communications, 2022 The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.
Acong Yang +5 more
doaj +1 more source
From Linear Genes to Epigenetic Inheritance of Three-dimensional Epigenomes [PDF]
, 2011 Fifty years ago Jacob and Monod reported their findings on the regulation of gene activity. Working on lambda bacteriophage lysogeny and the regulation of the production of an enzyme that cleaves lactose, they observed that its production was induced by ...
Cavalli, Giacomo
core +3 more sources
TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection
JHEP Reports, 2020 Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai +9 more
doaj +1 more source
Stochastic modeling of regulation of gene expression by multiple small RNAs
, 2011 A wealth of new research has highlighted the critical roles of small RNAs (sRNAs) in diverse processes such as quorum sensing and cellular responses to stress.
Baker, Charles +2 more
core +1 more source
Structural basis underlying viral hijacking of a histone chaperone complex
Nature Communications, 2016 The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang +6 more
doaj +1 more source
The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
Genome Biology, 2017 Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar +12 more
doaj +1 more source
Switching and diffusion models for gene regulation networks [PDF]
, 2009 We analyze a hierarchy of three regimes for modeling gene regulation. The most complete model is a continuous time, discrete state space, Markov jump process.
Cao Y. +3 more
core +2 more sources
Multi-locus CRISPRi targeting with a single truncated guide RNA
Nature CommunicationsA critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here,
Molly M. Moore +14 more
doaj +1 more source