Results 41 to 50 of about 2,989,814 (357)

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

Genome Biology, 2017
Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar, Aina M. Mas, Jovanna González, Dannys Martinez, Alejandro Athie, Xabier Morales, Mikel Galduroz, Ivan Raimondi, Elena Grossi, Shuling Guo, Ana Rouzaut, Igor Ulitsky, Maite Huarte   +12 more
doaj   +1 more source

Interaction and cross-talk between non-coding RNAs. [PDF]

, 2017
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir, Imai-Sumida, Mitsuho, Tanaka, Yuichiro, Yamamura, Soichiro   +3 more
core   +2 more sources

TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance

Nature Communications, 2022
The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.
Acong Yang, Xavier Bofill-De Ros, Ryan Stanton, Tie-Juan Shao, Patricia Villanueva, Shuo Gu   +5 more
doaj   +1 more source

Multi-locus CRISPRi targeting with a single truncated guide RNA

Nature Communications
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here,
Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm   +14 more
doaj   +1 more source

Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells

Neoplasia: An International Journal for Oncology Research, 2011
Invasiveness, cellular atypia, and proliferation are hallmarks of malignant gliomas. To effectively target each of these characteristics, it is important to understand their sequence during tumorigenesis. However, because most gliomas are diagnosed at an
Oltea Sampetrean, Isako Saga, Masaya Nakanishi, Eiji Sugihara, Raita Fukaya, Nobuyuki Onishi, Satoru Osuka, Masaki Akahata, Kazuharu Kai, Hachiro Sugimoto, Atsushi Hirao, Hideyuki Saya   +11 more
doaj   +1 more source

Effects of chronic browsing on life‐history traits of an irruptive large herbivore population

Population Ecology, EarlyView.
This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji, Kazutaka M. Takeshita, Hiroshi Takahashi, Hiromasa Igota, Mayumi Ueno, Yukiko Matsuura, Takashi Ikeda, Ryo Yoshizawa, Hino Takafumi, Tsuyoshi Yoshida   +9 more
wiley   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression. [PDF]

, 2019
While genetic variation at chromatin loops is relevant for human disease, the relationships between contact propensity (the probability that loci at loops physically interact), genetics, and gene regulation are unclear.
Benaglio, Paola, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A, Greenwald, William W, Jakubosky, David, Li, He, Matsui, Hiroko, Schmitt, Anthony, Selvaraj, Siddarth, Smith, Erin N   +10 more
core   +2 more sources

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Hormone-Mediated Gene-Specific Translation Regulation [PDF]

, 2016
The central role of translation regulation in the control of critical cellular processes has long been recognized. Yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to specific stimuli has only ...
Alonso, José, Brumós, Javier, Merchante, Catharina, Stepanova, Anna, Yun, Jeonga   +4 more
core