Results 81 to 90 of about 786,474 (343)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The hardwiring of development: Organization and function of genomic regulatory systems [PDF]

, 1997
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core  

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves [PDF]

, 2013
A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes
Abe, Allemeersch, Balazadeh, Baudry, Benjamini, Borevitz, Brady, Breeze, Bu, Castrillo, Denby, Dobi, Edgar, Fan, Feys, Fujita, Gilmour, Guo, Haake, Hao, He, Higo, Hu, Jensen, Kel, Kerr, Kilian, Libault, Liu, Maere, Mandaokar, Matys, Medina, Mengiste, Mitsuda, Nakashima, Niu, Ooka, Ou, Park, Penfold, Penfold, Pruneda-Paz, Puranik, Riechmann, Sakuma, Schuhegger, Solano, Stegle, Stracke, Tissier, Tran, Wettenhall, Windram, Winter, Yoshida, Zheng, Zou, Çevik   +58 more
core   +1 more source

HGATLink: single-cell gene regulatory network inference via the fusion of heterogeneous graph attention networks and transformer

BMC Bioinformatics
Background Gene regulatory networks (GRNs) involve complex regulatory relationships between genes and play important roles in the study of various biological systems and diseases.
Yao Sun, Jing Gao
doaj   +1 more source

Tightly regulated expression of Autographa californica multicapsid nucleopolyhedrovirus immediate early genes emerges from their interactions and possible collective behaviors. [PDF]

PLoS ONE, 2015
To infect their hosts, DNA viruses must successfully initiate the expression of viral genes that control subsequent viral gene expression and manipulate the host environment.
Chikako Ono, Masanao Sato, Hitomi Taka, Shin-ichiro Asano, Yoshiharu Matsuura, Hisanori Bando   +5 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

D3GRN: a data driven dynamic network construction method to infer gene regulatory networks

BMC Genomics, 2019
Background To infer gene regulatory networks (GRNs) from gene-expression data is still a fundamental and challenging problem in systems biology. Several existing algorithms formulate GRNs inference as a regression problem and obtain the network with an ...
Xiang Chen, Min Li, Ruiqing Zheng, Fang-Xiang Wu, Jianxin Wang   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Information processing at the foxa node of the sea urchin endomesoderm specification network [PDF]

, 2010
The foxa regulatory gene is of central importance for endoderm specification across Bilateria, and this gene lies at an essential node of the well-characterized sea urchin endomesoderm gene regulatory network (GRN). Here we experimentally dissect the cis-
Arenas-Mena, Ben-Tabou de-Leon, Boyle, Brown, Burtscher, Croce, E. H. Davidson, Friedman, Hiruta, Hong, Kim, Lee, Livant, Logan, Minokawa, Nam, Oliveri, Peter, Range, Rast, Revilla-i-Domingo, Rottinger, S. B.-T. de-Leon, Smith, Suri, Wahl, Wikramanayake   +26 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source