Results 121 to 130 of about 11,201,470 (335)

Effect Size Estimation and Misclassification Rate Based Variable Selection in Linear Discriminant Analysis [PDF]

, 2012
Supervised classifying of biological samples based on genetic information, (e.g. gene expression profiles) is an important problem in biostatistics. In order to find both accurate and interpretable classification rules variable selection is indispensable.
Klaus, Bernd
core   +1 more source

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics

PLoS ONE, 2018
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S.
D. Mav, Ruchir R. Shah, Brian E. Howard, Scott S. Auerbach, P. Bushel, Jennifer B. Collins, D. Gerhold, R. Judson, Agnes L. Karmaus, Elizabeth A. Maull, Donna L. Mendrick, B. A. Merrick, Nisha S. Sipes, Daniel L. Svoboda, R. Paules   +14 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Quantifying selection in immune receptor repertoires

, 2014
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination ...
Callan Jr., Curtis G., Elhanati, Yuval, Mora, Thierry, Murugan, Anand, Walczak, Aleksandra M.   +4 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Positive Selection on Mammalian Immune Genes—Effects of Gene Function and Selective Constraint

Molecular Biology and Evolution
Abstract Genome-wide analyses of various taxa have repeatedly shown that immune genes are important targets of positive selection. However, little is known about what factors determine which immune genes are under positive selection. To address this question, we here focus on the mammalian immune system and investigate the importance of ...
Mridula Nandakumar, Max Lundberg, Fredric Carlsson, Lars Råberg   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression

, 2014
Inter-individual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging.
Alexander Cagan, Belyaev, Darvasi, Enrico Petretto, Frank W. Albert, François Besnier, Henrike O. Heyne, Irina Z. Plyusnina, Leonid Kruglyak, Lyudmila Trut, Maxime Rotival, Rimma Kozhemyakina, Ronald Nelson, Susann Lautenschläger, Svante Pääbo, Torsten Schöneberg, Örjan Carlborg   +16 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

GFLASSO-LR: Logistic Regression with Generalized Fused LASSO for Gene Selection in High-Dimensional Cancer Classification

Computers
Advancements in genomic technologies have paved the way for significant breakthroughs in cancer diagnostics, with DNA microarray technology standing at the forefront of identifying genetic expressions associated with various cancer types.
Ahmed Bir-Jmel, Sidi Mohamed Douiri, Souad El Bernoussi, Ayyad Maafiri, Yassine Himeur, Shadi Atalla, Wathiq Mansoor, Hussain Al-Ahmad   +7 more
doaj   +1 more source