Results 191 to 200 of about 7,554,622 (397)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Plasmodium falciparum var Gene Silencing Is Determined bycisDNA Elements That Form Stable and Heritable Interactions

, 2011
Lakshmi Swamy, Borko Amulic, Kirk Deitsch   +2 more
openalex   +1 more source

Silencing the SLB3 transcription factor gene decreases drought stress tolerance in tomato

, 2020
Ziyu Wang, Yufang Bao, Pei Tong, Tai-ru Wu, Xuhua Du, Meng-xi HE, Yue Wang, Qifeng Liu, Huanhuan Yang, Jingbin Jiang, He Zhang, Jingfu Li, Tingting Zhao, Xiangyang Xu   +13 more
openalex   +1 more source

Botrytis cinerea small RNAs are associated with tomato AGO1 and silence tomato defense-related target genes supporting cross-kingdom RNAi [PDF]

, 2023
Baoye He, Qiang Cai, Arne Weiberg, Wei Li, An-Po Cheng, Shouqiang Ouyang, Katherine A. Borkovich, Jason Stajich, Cei Abreu‐Goodger, Hailing Jin   +9 more
openalex   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

The efficacy of oligonucleotide-based gene therapeutics in gene silencing. [PDF]

Theranostics
Patra C, Hussein Z, Ace VD, Misnik EV, Rybalko DS, Salimova AA, Ereshko DS, Dubovichenko MV, Nour MAY, Drozd VS, Kolpashchikov DM.   +10 more
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

RG motifs promote piRNA-mediated gene silencing in C. elegans. [PDF]

Nucleic Acids Res
Wallis DC, Phillips CM.
europepmc   +1 more source

Sugarcane Mosaic Virus-Based Gene Silencing in Nicotiana benthamiana [PDF]

, 2017
Sajed Ali, Idrees Ahmad Nasir, Muhammad Rafiq, Shahid Javed Butt, Farooq Ihsan, Abdul Qayyum Rao, Tayyab Husnaın   +6 more
openalex   +1 more source

On the Effectivity of Gene Silencing Induction in Fall Armyworm (Spodoptera Frugiperda) Using Specific dsRNA [PDF]

, 2020
Salvador Ricardo
openalex   +1 more source