Results 21 to 30 of about 6,519,783 (149)

Visible gland constantly traces virus-induced gene silencing in cotton

Frontiers in Plant Science, 2022
A virus-induced gene silencing (VIGS) system was established to induce endogenous target gene silencing by post-transcriptional gene silencing (PTGS), which is a powerful tool for gene function analysis in plants.
Zhanfeng Si, Huaitong Wu, Huaitong Wu, Yue Tian, Zhiyuan Zhang, Tianzhen Zhang, Tianzhen Zhang, Yan Hu, Yan Hu   +8 more
doaj   +1 more source

Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction.

PLoS Genetics, 2022
Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-specific nucleation sites, is critical for stable gene silencing.
R A Greenstein, Henry Ng, Ramon R Barrales, Catherine Tan, Sigurd Braun, Bassem Al-Sady   +5 more
doaj   +1 more source

MIGS as a Simple and Efficient Method for Gene Silencing in Rice

Frontiers in Plant Science, 2018
MiRNA-induced gene silencing (MIGS) technology is a special kind of RNA interference technology that uses miR173 to mediate the production of trans-acting siRNA (ta-siRNA) to achieve target gene silencing.
Xuelian Zheng, Lijia Yang, Qian Li, Linyi Ji, Aiting Tang, Lili Zang, Kejun Deng, Jianping Zhou, Yong Zhang   +8 more
doaj   +1 more source

Transcriptional gene silencing in humans

Nucleic Acids Research, 2016
It has been over a decade since the first observation that small non-coding RNAs can functionally modulate epigenetic states in human cells to achieve functional transcriptional gene silencing (TGS).
M. Weinberg, K. Morris
semanticscholar   +1 more source

Virus Recovery Is Induced in Brome mosaic virus p2 Transgenic Plants Showing Synchronous Complementation and RNA-2-Specific Silencing

Molecular Plant-Microbe Interactions, 2000
Nicotiana benthamiana plants expressing Brome mosaic virus (BMV) p2 protein complemented replication of RNAs1+3 but, surprisingly, supported little or no replication of RNA-2. Despite this, the p2 transgenic plants were able to support systemic migration
Lakshminarayan M. Iyer, Timothy C. Hall
doaj   +1 more source

Transgene Was Silenced in Hybrids between Transgenic Herbicide-Resistant Crops and Their Wild Relatives Utilizing Alien Chromosomes

Plants, 2022
The commercialization of transgenic herbicide-resistant (HR) crops may cause gene flow risk. If a transgene in progenies of transgenic crops and wild relatives is silencing, these progenies should be killed by the target herbicide, thus, the gene flow ...
Zicheng Shao, Lei Huang, Yuchi Zhang, Sheng Qiang, Xiaoling Song   +4 more
doaj   +1 more source

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Journal of the American Chemical Society, 2014
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery of the siRNA to hepatocytes in vitro and in vivo.
Jayaprakash K Nair, J. Willoughby, A. Chan, K. Charissé, Md. Rowshon Alam, Qianfan Wang, M. Hoekstra, P. Kandasamy, A. Kel'in, S. Milstein, Nate Taneja, Jonathan O’Shea, Sarfraz Shaikh, Ligang Zhang, R. J. van der Sluis, M. Jung, Akin Akinc, R. Hutabarat, S. Kuchimanchi, K. Fitzgerald, Tracy S. Zimmermann, T. V. van Berkel, M. Maier, K. G. Rajeev, M. Manoharan   +24 more
semanticscholar   +1 more source

Simultaneous gene expression and multi-gene silencing in Zea mays using maize dwarf mosaic virus

BMC Plant Biology, 2021
Background Maize dwarf mosaic virus (MDMV), a member of the genus Potyvirus, infects maize and is non-persistently transmitted by aphids. Several plant viruses have been developed as tools for gene expression and gene silencing in plants. The capacity of
Wenshuang Xie, Dee Marie Marty, Junhuan Xu, Nitika Khatri, Kristen Willie, Wanderson Bucker Moraes, Lucy R. Stewart   +6 more
doaj   +1 more source

Chromosome-specific NOR inactivation explains selective rRNA gene silencing and dosage control in Arabidopsis

Genes & Development, 2016
Given the near sequence identity of ribosomal RNA (rRNA) genes within a species, it is unclear how specific rRNA genes are reproducibly chosen for silencing. Chandrasekhara et al.
Chinmayi Chandrasekhara, Gireesha Mohannath, Todd Blevins, Frédéric Pontvianne, C. Pikaard   +4 more
semanticscholar   +1 more source

GENE SILENCING

The Professional Medical Journal, 2018
Objectives: Cancer, the most complex group of genetic disorders results due to over expression or mutation of oncogenes/molecules involved in cell signaling pathways. KRAS is an oncogene that encodes a small GTPase protein with two isoforms KRasA & KRasB
F. Khan, Ghazala Irshad, Samra Hafiz
semanticscholar   +1 more source