Results 21 to 30 of about 7,554,622 (397)
F1000Research, 2023 Background: Many studies have demonstrated the utility of machine learning (ML) methods for genomic prediction (GP) of various plant traits, but a clear rationale for choosing ML over conventionally used, often simpler parametric methods, is still ...
Aalt D.J. van Dijk +4 more
doaj +1 more source
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles [PDF]
, 2008 Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate
De Smedt, Stefaan +4 more
core +1 more source
International Journal of Genomics, 2013 Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disease affecting mainly motor neurons and often leads to paralysis and death in extreme cases.
Santosh Shinde +2 more
doaj +1 more source
Epigenetic silencing in transgenic plants
Frontiers in Plant Science, 2015 Epigenetic silencing is a natural phenomenon in which the expression of gene is regulated through modifications of DNA, RNA or histone proteins. It is a mechanism for defending host genomes against the effects of transposable element, viral infection and
Sarma eRajeev Kumar +2 more
doaj +1 more source
RNA-Mediated Gene Silencing Signals Are Not Graft Transmissible from the Rootstock to the Scion in Greenhouse-Grown Apple Plants Malus sp. [PDF]
, 2012 RNA silencing describes the sequence specific degradation of RNA targets. Silencing is a non-cell autonomous event that is graft transmissible in different plant species.
Bai +37 more
core +3 more sources
浙江大学学报. 农业与生命科学版, 2008 The term virus-induced gene silencing' (VIGS) was first used to describe the phenomenon of recovery from virus infection, a natural plant antiviral mechanism, which recently has been exploited as a genetic technique involving recombinant viruses with a ...
XU You-ping +4 more
doaj +1 more source
Cell Reports, 2022 Summary: X chromosome inactivation (XCI) is mediated by the non-coding RNA Xist, which directs chromatin modification and gene silencing in cis. The RNA binding protein SPEN and associated corepressors have a central role in Xist-mediated gene silencing.
Joseph S. Bowness +8 more
doaj +1 more source
DNA nanostructures coordinate gene silencing in mature plants
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Plant bioengineering will be necessary to sustain plant biology and agriculture, where the delivery of biomolecules such as DNA, RNA, or proteins to plant cells is at the crux of plant biotechnology. Here, we show that DNA nanostructures can
Huan Zhang +8 more
semanticscholar +1 more source
Conditional U1 gene silencing in Toxoplasma gondii [PDF]
, 2015 The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing.
Blackman, Michael J. +10 more
core +8 more sources
Application of RNA Interference to Root-Knot Nematode Genes Encoding Esophageal Gland Proteins
Molecular Plant-Microbe Interactions, 2005 Plant parasitic nematodes have been, so far, refractory to transformation or mutagenesis. The functional analysis of nematode genes relies on the development of reverse genetic tools adapted to these obligate parasites.
M.-N. Rosso +4 more
doaj +1 more source