Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
Angewandte Chemie, 2012 Special (lipid) delivery: The role of the ionizable lipid pK(a) in the in vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group modifications to the lipids.
M. Jayaraman +18 more
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Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
Epigenetics & Chromatin, 2010 Background X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist.
Tang Y Amy +5 more
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Molecular Plant-Microbe Interactions, 2019 DNA transformation and homology-based transcriptional silencing are frequently used to assess gene function in Phytophthora spp. Since unplanned side-effects of these tools are not well-characterized, we used P.
Andrea L. Vu +3 more
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Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. [PDF]
, 1990 E C Park, J W Szostak
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Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.
Cold Spring Harbor Perspectives in Biology, 2013 Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed with heterochromatin by rearrangement or transposition.
S. Elgin, G. Reuter
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The RNA interference revolution
Brazilian Journal of Medical and Biological Research, 2005 The discovery of double-stranded RNA-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology.
G. Lenz
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The Scientific World Journal, 2013 We evaluated effect of dual gene silencing of Hsp27 and c-FLIP in doxazosin-induced apoptosis of PC-3 cell. After transfection using Hsp27 and c-FLIP siRNA mixture (dual silencing), doxazosin treatment was done at the concentrations of 1, 10, and 25 μM ...
Sang Soo Kim +5 more
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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. [PDF]
, 1995 Carrie Baker Brachmann +5 more
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Carcinogenic Nickel Silences Gene Expression by Chromatin Condensation and DNA Methylation: a New Model for Epigenetic Carcinogens [PDF]
, 1995 Y.-W. Lee +8 more
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Effect of a silencing suppressor gene towards the expression of VP2 protein of highly virulent infectious bursal disease virus in tobacco [PDF]
Journal of BioScience and Biotechnology, 2013 Gene silencing has been recognized as an important factor, which influence the expression of heterologous protein delivered via plant-viral based system.
Siti-Hasmah Mohtar +3 more
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