Results 71 to 80 of about 7,098,593 (382)

Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]

PLoS Genetics, 2008
Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris, Sharon Santoso, Anne-Marie Turner, Chiara Pastori, Peter G Hawkins   +4 more
doaj   +1 more source

Gene silencing by CRISPR interference in mycobacteria

Nature Communications, 2015
Recombination-based tools for introducing targeted genomic mutations in Mycobacterium tuberculosis are not efficient due to higher rate of illegitimate recombination compared with homologous DNA exchange.
Eira Choudhary, P. Thakur, Madhu Pareek, Nisheeth Agarwal   +3 more
semanticscholar   +1 more source

Silencing of Developmental Genes in Hydra

Developmental Biology, 1999
Numerous developmental control genes have been isolated in a variety of organisms by either homology cloning or system-specific strategies. Functional genetic tests, however, are available for only a few model organisms and particularly are missing in a number of animals that occupy key positions for understanding the evolution of development and gene ...
Ingrid Endl, Jan U. Lohmann, Thomas C. G. Bosch   +2 more
openaire   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

An Analysis of Putative Roles for the CCR4-NOT Deadenylase-Complex Subunit Regena (NOT2) in microRNA-Mediated Gene Silencing in \u3cem\u3eDrosophila Melanogaster\u3c/em\u3e [PDF]

, 2013
microRNAs (miRNAs) are one class of small non-coding ribonucleic acid (RNA) molecules essential to development and homeostasis in plants and animals. miRNAs silence gene expression through complementary base pairing with target gene messenger RNAs and ...
Erickson, Jasper, Gillmore, Colleen, Knox, James D., Reinke, Catherine A.   +3 more
core   +1 more source

Development and application of a virus-induced gene silencing protocol for the study of gene function in narrow-leafed lupin

Plant Methods, 2021
Background Lupins are promising protein crops with an increasing amount of genomic and transcriptomic resources. The new resources facilitate the in silico identification of candidate genes controlling important agronomic traits.
Davide Mancinotti, Maria Cecilia Rodriguez, Karen Michiko Frick, Bjørn Dueholm, Ditte Goldschmidt Jepsen, Niels Agerbirk, Fernando Geu-Flores   +6 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing [PDF]

, 2011
MicroRNAs (miRNAs) are prevalent regulatory RNAs that mediate gene silencing and play key roles in diverse cellular processes. While synthetic RNA-based regulatory systems that integrate regulatory and sensing functions have been demonstrated, the lack ...
Aagaard, An, Ballarino, Bartlett, Bauer, Bayer, Beisel, Beisel, Berens, Boudreau, Cai, Chase L. Beisel, Chen, Christina D. Smolke, Desai, Dickins, Friedman, Gregory, Grimm, Guil, Han, Han, Han, Hermann, Jenison, Kedde, Kevin G. Hoff, Kiga, Koizumi, Kumar, Lee, Lee, Lee, McBride, Muller, Osborne, Sinha, Stephanie J. Culler, Stern, Stoltenburg, Suess, Sun, Tuerk, Tuleuova, Wang, Wang, Weigand, Wieland, Wilson, Win, Win, Wiznerowicz, Xia, Yvonne Y. Chen, Zeng, Zeng, Zeng, Zeng, Zhang, Zhang   +59 more
core   +8 more sources

Arabidopsis Small RNAs and Their Targets During Cyst Nematode Parasitism

Molecular Plant-Microbe Interactions, 2008
Plant-parasitic cyst nematodes induce the formation of specialized feeding cells in infected roots, which involves plant developmental processes that have been shown to be influenced by microRNAs (miRNAs) and other small RNAs.
Tarek Hewezi, Peter Howe, Tom R. Maier, Thomas J. Baum   +3 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source