Results 161 to 170 of about 12,260,520 (401)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

An Engineered RNase P Ribozyme Effectively Reduces Human Coronavirus 229E Gene Expression and Growth in Human Cells

Zoonotic Diseases
The human coronavirus 229E (HCoV-229E) is a member of the human coronavirus family that includes SARS-CoV-2, the causative agent of COVID-19. Developing antiviral strategies and compounds is crucial to treat and prevent HCoV-229E infections and the ...
Yujun Liu, Bin Yan, Hao Gong, Fenyong Liu   +3 more
doaj   +1 more source

Gene modification: Targeting in mammalian cells [PDF]

, 1985
Tom Maniatis
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Lipofection improves gene targeting efficiency in E14 TG2a mouse embryonic stem cells [PDF]

, 2009
Electroporation has been the method of election for transfection of murine embryonic stem cells for over 15 years; however, it is a time consuming protocol because it requires large amounts of DNA and cells, as well as expensive and delicate equipment ...
ALONSO MORALES, ROGELIO ALEJANDRO, ALONSO MORALES, ROGELIO ALEJANDRO, BARBABOSA PLIEGO, ALBERTO, BARBABOSA PLIEGO, ALBERTO, Cajero Juárez, Marcos, Cajero Juárez, Marcos, LOPEZ HEYDECK, SANDRA MARICRUZ, LOPEZ HEYDECK, SANDRA MARICRUZ, MARTINEZ CASTAÑEDA, JOSE SIMON, MARTINEZ CASTAÑEDA, JOSE SIMON, Robles González, Jose Francisco, Robles González, Jose Francisco, VAZQUEZ CHAGOYAN, JUAN CARLOS, VAZQUEZ CHAGOYAN, JUAN CARLOS   +13 more
core  

Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology. [PDF]

, 1989
James Ellis, Alan Bernstein
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Establishment of a stable transfection and gene targeting system in Babesia divergens. [PDF]

Front Cell Infect Microbiol, 2023
Cubillos EFG, Snebergerova P, Borsodi S, Reichensdorferova D, Levytska V, Asada M, Sojka D, Jalovecka M.   +7 more
europepmc   +1 more source

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. [PDF]

, 1989
K Nocka, S Majumder, Benoı̂t Chabot, Prabir Ray, Mario Cervone, Alan Bernstein, Peter Besmer   +6 more
openalex   +1 more source