Results 171 to 180 of about 1,756,365 (358)

Generation of Mouse Model of Hemophilia A by Introducing Novel Mutations, Using CRISPR/Nickase Gene Targeting System. [PDF]

Cell J, 2023
Shamsara M, Jamshidizad A, Rahim-Tayefeh A, Davari M, Rajabi Zangi A, Masoumi F, Zomorodipour A.   +6 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Efficient mutagenesis targeting the IFNAR1 gene in mice using a combination of Cas9 protein and dual gRNAs.

, 2021
Zhihui Liu, Zongxiang Chen, Jingya Di, Zhisong Wang, Yongxia Zhang, Jinshan Li, Liyou An, Giorgio Antonio Presicce, Lanjun Liu, Fuliang Du   +9 more
openalex   +1 more source

Targetable gene fusions in T-cell lymphoma [PDF]

, 2016
Megan S. Lim
openalex   +1 more source

Data from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma

, 2023
Wojciech K. Mydlarz, Mamoru Uemura, Sun Tae Ahn, Patrick Hennessey, Steven D. Chang, Semra Demokan, Wenyue Sun, Chunbo Shao, Justin Bishop, Julie Krosting, Elizabeth Mambo, William H. Westra, Patrick K. Ha, David Sidransky, Joseph A. Califano   +14 more
openalex   +1 more source

A knockout-first model of H3f3a gene targeting leads to developmental lethality. [PDF]

Genesis, 2023
Bush K, Cervantes V, Yee JQ, Klein RH, Knoepfler PS.   +4 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Precise and heritable gene targeting in rice using a sequential transformation strategy. [PDF]

Cell Rep Methods, 2023
Zhang W, Wang R, Kong D, Peng F, Chen M, Zeng W, Giaume F, He S, Zhang H, Wang Z, Kyozuka J, Zhu JK, Fornara F, Miki D.   +13 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source