Results 11 to 20 of about 708,347 (229)
JOR Spine, 2023 There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu +6 more
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Gene targeting in livestock [PDF]
Bioscientifica Proceedings, 2019 The development of nuclear transfer from tissue culture cells in livestock made it possible in principle to produce animals with subtle, directed genetic changes by in vitro modification of nuclear donor cells. In the short period since nuclear transfer was first performed, gene targeting in livestock has become a reality.
Jim McWhir +2 more
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CRISPR-Cas9-mediated functional dissection of 3'-UTRs. [PDF]
, 2017 Many studies using reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression by controlling mRNA stability and translation.
Ahituv, Nadav +6 more
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Targeting Epilepsy Genes [PDF]
Neuron, 1996 In medieval art it was traditional to show a demon emanating from a suffering epileptic at the conclusion of a seizure, with concern clearly evident regarding its inevitable reappearance. In this century, anticonvulsant drugs have been developed for their ability to control, rather than prevent or reverse, seizure disorders.
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Therapeutic gene targeting [PDF]
Gene Therapy, 1998 Gene targeting is the use of homologous recombination to make defined alterations to the genome. One of the possible outcomes of gene targeting is the accurate correction of genetic defects, and this would make it the ideal method of gene therapy for single gene disorder.
Andrew C.G. Porter, Rafael J. Yáñez
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Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature [PDF]
, 2009 We performed in vivo phage display in the stroke prone spontaneously hypertensive rat, a cardiovascular disease model, and the normotensive Wistar Kyoto rat to identify cardiac targeting peptides, and then assessed each in the context of viral gene ...
Andrew H. Baker +26 more
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Gene Editing and Genotoxicity: Targeting the Off-Targets [PDF]
Frontiers in Genome Editing, 2020 Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modification of a DNA sequence is now possible in mature human somatic cells including stem and progenitor cells with increasing degrees of efficiency.
Blattner G. +3 more
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CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy
Viruses, 2018 Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level.
Shuliang Chen, Xiao Yu, Deyin Guo
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Nature Communications, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
HaoRan Tang +12 more
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Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]
, 2017 Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G +2 more
core +3 more sources