Results 11 to 20 of about 12,501,640 (402)
Gene targeting in livestock. [PDF]
Bioscientifica Proceedings, 2019 The development of nuclear transfer from tissue culture cells in livestock made it possible in principle to produce animals with subtle, directed genetic changes by in vitro modification of nuclear donor cells.
A. Thomson, M. Marques, J. Mcwhir
semanticscholar +3 more sources
Gene targeting in plants [PDF]
The EMBO Journal, 1987 Although the generation of transgenic plants is now routine, the integration of foreign genetic information has so far been at random sites in the genome. We now present evidence for directed integration into a predicted location in the host plant genome.
Augustyn Bogucki +3 more
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Cell, 2004 When it comes to silencing genes in mice, not all approaches are equal. An example published in this issue of Cell (Patrucco et al., 2004) suggests that caution should be used when validating potential drug targets by genetic disruption.
Michael D. Waterfield +3 more
openaire +2 more sources
T-Gene: improved target gene prediction [PDF]
Bioinformatics, 2019 Abstract Motivation Identifying the genes regulated by a given transcription factor (TF) (its ‘target genes’) is a key step in developing a comprehensive understanding of gene regulation. Previously, we developed a method (CisMapper) for predicting the target genes of a TF based solely on the ...
Timothy O’Connor +3 more
openaire +5 more sources
Targeting Epilepsy Genes [PDF]
Neuron, 1996 In medieval art it was traditional to show a demon emanating from a suffering epileptic at the conclusion of a seizure, with concern clearly evident regarding its inevitable reappearance. In this century, anticonvulsant drugs have been developed for their ability to control, rather than prevent or reverse, seizure disorders.
openaire +3 more sources
Targeting p53 pathways: mechanisms, structures and advances in therapy
Signal Transduction and Targeted Therapy, 2023 The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang +3 more
semanticscholar +1 more source
Zoonotic Diseases, 2023 Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro.
Bin Yan +4 more
doaj +1 more source
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. [PDF]
, 2016 The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects.
Adkisson, Michael +9 more
core +4 more sources
CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation
Nature Communications, 2018 Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse.
D. Miki +4 more
semanticscholar +1 more source
Design of double-walled carbon nanotubes for biomedical applications [PDF]
, 2012 Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M. +8 more
core +2 more sources