Results 211 to 220 of about 12,501,640 (402)

An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. [PDF]

, 1992
Nissim Benvenisty, A Leder, Annie F. Kuo, Philip Leder   +3 more
openalex   +1 more source

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

Cell, 2014
Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiao-Yang Zhao, W. Si, Wei Li, A. Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuo-min Zhou, Tianqing Li, apple apple, X. Pu, F. Wang, Shaohui Ji, Qi Zhou, Xingxu Huang, W. Ji, J. Sha   +27 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Lethality rescue and long-term amelioration of a citrullinemia type I mouse model by neonatal gene-targeting combined to SaCRISPR-Cas9. [PDF]

Mol Ther Methods Clin Dev, 2023
Lisjak M, Iaconcig A, Guarnaccia C, Vicidomini A, Moretti L, Collaud F, Ronzitti G, Zentilin L, Muro AF.   +8 more
europepmc   +1 more source

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

, 1992
Thomas M. Magin, Jim McWhir, David W. Melton   +2 more
openalex   +1 more source

Targeted disruption of the Dictyostelium RMLC gene produces cells defective in cytokinesis and development. [PDF]

, 1994
Lan S. Chen, Bruce Ostrow, Sherrie Tafuri, Rex L. Chisholm   +3 more
openalex   +1 more source

Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial blight of rice.

The Plant Journal, 2015
Junhui Zhou, Zhao Peng, Juying Long, Davide Sosso, Bo Liu, J. Eom, Sheng Huang, Sanzhen Liu, C. Vera Cruz, W. Frommer, F. White, Bing Yang   +11 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting. [PDF]

Anim Cells Syst (Seoul), 2022
Jeong YJ, Cho J, Kwak J, Sung YH, Kang BC.   +4 more
europepmc   +1 more source