Results 211 to 219 of about 1,094,612 (219)
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2012
Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
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Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
openaire +2 more sources
Targeting the “species gene ensemble”
Hippocampus, 2002AbstractThe members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the ‘genetic background’ leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout
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Target genes of homeodomain proteins
BioEssays, 1999Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
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