Results 251 to 260 of about 1,756,365 (358)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Comprehensive analysis of off-target and on-target effects resulting from liver-directed CRISPR-Cas9-mediated gene targeting with AAV vectors. [PDF]

Mol Ther Methods Clin Dev
Singh K, Fronza R, Evens H, Chuah MK, VandenDriessche T.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of targeted GFP - Hox gene fusions during mouse embryogenesis

, 1998
Alan R. Godwin, H. Scott Stadler, Kotoka Nakamura, Mario R. Capecchi   +3 more
openalex   +2 more sources

Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection. [PDF]

Nat Biomed Eng
Roth TL, Lu J, McClellan A, Kernick C, Takacsi-Nagy O, Satpathy AT.   +5 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Herpes simplex virus-based nerve targeting gene therapy in pain management

, 2014
Darren Wolfe, James R. Goss, David Krisky, James Wechuck   +3 more
openalex   +2 more sources

Non-electrophilic NRF2 activators promote wound healing in human keratinocytes and diabetic mice and demonstrate selective downstream gene targeting. [PDF]

Sci Rep
Barakat M, Han C, Chen L, David BP, Shi J, Xu A, Skowron KJ, Johnson T, Woods RA, Ankireddy A, Reddy SP, Moore TW, DiPietro LA.   +12 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Simple promotion of Cas9 and Cas12a expression improves gene targeting via an all-in-one strategy. [PDF]

Front Plant Sci
Cheng Y, Zhang L, Li J, Dang X, Zhu JK, Shimada H, Miki D.   +6 more
europepmc   +1 more source