Results 21 to 30 of about 622,762 (337)

Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications [PDF]

Acta Medica Iranica, 2010
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery.
Kianoush Khosravi-Darani, Mohamaad Reza Mozafari, Ladan Rashidi, Mehrdad Mohammadi   +3 more
doaj   +1 more source

The challenging nature of primary T lymphocytes for transfection: Effect of protamine sulfate on the transfection efficiency of chemical transfection reagents

Research in Pharmaceutical Sciences, 2020
Background and purpose: The optimization of an effective non-viral gene delivery method for genetic manipulation of primary human T cells has been a major challenge in immunotherapy researches.
Ilnaz Rahimmanesh, Mehdi Totonchi, Hossein Khanahmad   +2 more
doaj   +1 more source

1-aminocyclopropane-1-carboxylate deaminase-producing Agrobacterium tumefaciens has higher ability for gene transfer into plant cells [PDF]

, 2008
Agrobacterium-mediated gene transfer is widely used for plant molecular genetics, and efficient techniques are required. Recent studies show that ethylene inhibits the gene transfer.
Ezura Hiroshi, Minamisawa Kiwamu, Nonaka Satoko, Sugawara Masayuki, Yuhashi Ken-ichi, 江面 浩   +5 more
core   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Birnstiel, Max L., Clausen, Henrik, Cotten, Matt, Dinter, André, Mechtler, Karl, Rusconi, Sandro, Thurnher, Martin, Wagner, Ernst   +8 more
core   +2 more sources

The effects of different combinations and varying concentrations of growth regulators on the regeneration of selected Turkish cultivars of melon [PDF]

, 2013
Cucurbits are an economically important family of plants. The majority of the vegetable production in Turkey, for example, derives from the species beloning to the family Cucurbitaceae. Despite the importance of cucurbits among vegetable crops worldwide,
Cetiner, Selim, Tekdal, Dilek, Çetiner, Selim   +2 more
core   +2 more sources

Construcción de un vector de expresión derivado de virus adenoasociados para corregir in vitro el defecto genético de la enfermedad de Morquio A

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La mucopolisacaridosis IV A (Morquio A) es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y ...
Luis Alejandro Barrera, Mónica A. Gutiérrez, Felipe García Vallejo, Shunji Tomatsu, Flavio Cerón, Carlos J. Alméciga Díaz, Martha C. Domínguez   +6 more
doaj   +1 more source

An Overview of the Use of Neural Networks for Data Mining Tasks [PDF]

, 2012
In the recent years the area of data mining has experienced a considerable demand for technologies that extract knowledge from large and complex data sources.
Alberts B, Alpaydin E, Ando T, Blake CL, Bramer MA, Castanheira LG, Han J, Lu H, Mitchell M, Ni X, Quinlan RJ, Rumelhart DE, Shafer JC, Shendure J, Simić D, Stahl F, Steinwart I, Surjandari I, Wei JS, Widrow B, Witten IH, Zaslavsky B, Zhang D   +22 more
core   +1 more source

Synthesis, characterization and evaluation of transfection efficiency of dexamethasone conjugated poly(propyleneimine) nanocarriers for gene delivery#

Pharmaceutical Biology, 2018
Context: Polypropylenimine (PPI), a cationic dendrimer with defined structure and positive surface charge, is a potent non-viral vector. Dexamethasone (Dexa) conveys to the nucleus through interaction with its intracellular receptor.
Bizhan Malaekeh-Nikouei, Mehdi Rezaee, Leila Gholami, Naghmeh Sanjar Mousavi, Reza Kazemi Oskuee   +4 more
doaj   +1 more source

Intellectual Property and Opportunities for Food Security in the Philippines [PDF]

, 2013
By 2050, the Philippine population is projected to increase by as much as 41 percent, from 99.9 million to nearly 153 million people. Producing enough food for such an expanding population and achieving food security remain a challenge for the Philippine
Alfonso, Antonio, Estigoy, Rodolfo, Grimes, Howard, Jones, Keith, Kowalski, Stanley P., Maredia, Karim, Payumo, Jane   +6 more
core   +3 more sources

Genetic Modification of T Cells

Biomedicines, 2016
Gene transfer technology and its application to human gene therapy greatly expanded in the last decade. One area of investigation that appears particularly promising is the transfer of new genetic material into T cells for the potential treatment of ...
Richard A. Morgan, Benjamin Boyerinas
doaj   +1 more source