Results 201 to 210 of about 156,482 (265)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Biomarkers in Colorectal Cancer: Clinically Relevant Diagnostic and Prognostic Molecular Features, and the Future of Precision Medicine. [PDF]

J Pers Med
Whitmer R, Sepulveda J, Gandhi J, Puri I, Gupta R.   +4 more
europepmc   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Case Report: A case of Rothmund-Thomson syndrome-like phenotype with an <i>ANAPC1</i> variant of uncertain significance and observed hair improvement. [PDF]

Front Med (Lausanne)
Huang C, Liu Q, Yang D.
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Single-cell RNA sequencing reveals depot-specific characteristics of adipose progenitor cells in ducks. [PDF]

Poult Sci
Wang Z, Yang C, Liu S, Jiang Y, Bai H, Chang G, Chen G, Zhao L.   +7 more
europepmc   +1 more source

Familial adenomatous polyposis (FAP) and its gene, APC

Cytogenetic and Genome Research, 1999
openaire   +2 more sources

Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk. [PDF]

Cancer Manag Res
Qi X, Hao S, Sun Y, Li M, Yang J, Kang L, Zhang L, Wang H.   +7 more
europepmc   +1 more source

Oligometastatic versus polymetastatic colon cancer: functional and genomic determinants of divergent metastatic trajectories. [PDF]

Explor Target Antitumor Ther
Sirica R, Picone C, Sabbatino F, Petrillo N, Cascella M, Santorsola M, Granata V, Ianniello M, Ruggiero R, Circelli L, Ciappina G, Berretta M, Savarese G, Ottaiano A.   +13 more
europepmc   +1 more source