Results 211 to 220 of about 156,482 (265)

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons. [PDF]

Neurobiol Pain
Truong V, Brougher J, Strassmaier T, Lu YL, George D, Price TJ, Obergrussberger A, Haedo RJ, Fertig N, Walsh P.   +9 more
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Advances in chemoprevention of familial adenomatous polyposis. [PDF]

Front Oncol
Li R, Cao R, Kang J, Li Y, Lin X, Zhang Z.   +5 more
europepmc   +1 more source

Identification, design, and <i>in vivo</i> proof of concept of a shared APC neoantigen delivered via a self-amplifying RNA containing virus-like nanoparticle for cancer vaccination. [PDF]

Front Immunol
Simmons AJ, Nikonova AS, Jonas CD, Pniewski KA, Upreti D, Perez MI, Adhikari S.   +6 more
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PICALM regulates a human microglial antigen presentation program in Alzheimer’s disease

De Strooper B, Borrie S, Pasciuto E, Moortel LV, Willems P, Moechars D, Thrupp N, Bourdely P, Snellinx A, T'Syen D, Li R, Lloyd A, Geary B, De Baene H, Albertini G, Sirvent DÁ, Mekkes N, Holtman I, Holstege H, Malysheva V, Mazzone M, Impens F, Fiers M, Sierksma A.   +23 more
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The Many Faces of the Tumor Suppressor Gene APC

Experimental Cell Research, 2001
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is a multifunctional protein involved in a wide variety of processes, including regulation of cell proliferation, cell migration, cell
Rachel Giles, Hans Clevers, H C Clevers   +2 more
exaly   +4 more sources

The APC gene in colorectal cancer

European Journal of Cancer, 2002
Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role in the majority of sporadic colorectal cancers. Colorectal tumours are known to arise through a gradual series of histological changes, the so-called 'adenoma-carcinoma' sequence, each accompanied ...
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The I1307K polymorphism of the APC gene in colorectal cancer

Gastroenterology, 1999
Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predisposition in Ashkenazi Jews. However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon ...
Prior, T. W., Chadwick, R. B., Papp, A. C., Arcot, A. N., Isa, A. M., Pearl, D. K., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, L. A., De la Chapelle, A.   +10 more
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Different Expressivity of two Adjacent Mutations of the APC Gene

Tumori Journal, 1999
Aims and background The phenotypic expression of different APC mutations in familial adenomatous polyposis (FAP) is variable: two to three variants of the disease have been defined based on the severity of colonic manifestations.
PRESCIUTTINI, SILVANO, Gismondi V, Scarcello E, Sala P, D'Elia F, Rossetti C, Caroti Ghelli C, Molina F, Groden J, MOSCA, FRANCO, Bertario L, Varesco L.   +11 more
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Study of the APC gene function in the mouse APC+/APC1638N model.

Neuro endocrinology letters, 2016
Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the presence of hundreds to thousands of benign polyps in the colon. If not removed prophylactically they represent a risk of developing malignant cancer with an almost 100% penentrance. FAP is induced by germline mutation in the APC gene.
Zuzana, Adamcikova, Lenka, Wachsmannova, Katarina, Hainova, Viola, Stevurkova, Vladimir, Holec, Sona, Ciernikova, Zuzana, Cierna, Pavol, Janega, Pavel, Babal, Michal, Mego, Vladimir, Zajac   +10 more
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