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Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons. [PDF]
Neurobiol PainTruong V +9 more
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Clinical exploration of first-line therapy in metastatic lung adenocarcinoma patients with negative or low PD-L1 expression: a retrospective cohort study. [PDF]
Front ImmunolXu K, Cai R, Sun Z, Wang C, Bao J.
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Mitochondrial dysfunction and autophagy activation underlie NK cell impairment induced by Cannabis. [PDF]
PLoS OneBolduc AA +4 more
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Biallelic germline MBD4 mutations predispose to colorectal polyposis, hypermutated AML, and schwannomas. [PDF]
Fam CancerCooper J +8 more
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The Many Faces of the Tumor Suppressor Gene APC
Experimental Cell Research, 2001Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer. Close examination of the function of APC has shown that it is a multifunctional protein involved in a wide variety of processes, including regulation of cell proliferation, cell migration, cell
Es, J.H. van, Giles, R.H., Clevers, J.C.
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The APC gene in colorectal cancer
European Journal of Cancer, 2002Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role in the majority of sporadic colorectal cancers. Colorectal tumours are known to arise through a gradual series of histological changes, the so-called 'adenoma-carcinoma' sequence, each accompanied ...
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