Results 231 to 240 of about 155,361 (266)

Mutations in the APC gene and their implications for protein structure and function

Current Opinion in Genetics & Development, 1995
An enormous number of germline and somatic mutations have been identified in the APC tumor suppressor gene. Nearly all of these mutations result in premature polypeptide chain termination, but the consequences to APC protein function are unknown. Recent advances, including the identification of an oligomerization domain, the localization of several ...
openaire   +2 more sources

The APC gene product and colorectal carcinogenesis.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1997
The adenomatous polyposis coli (APC) gene has been found to be mutated during the development of sporadic colorectal tumours as well as in familial adenomatous polyposis patients (FAP), mutations being somatic or germinal respectively. The gene product is truncated in the carboxyterminal region but the role of the APC protein in tumorigenesis is not ...
C, Bonneton, L, Larue, J P, Thiéry
openaire   +1 more source

APC gene and molecular diagnostics

2003
Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
openaire  

Identification of APC gene mutations in Italian APC patients by PCR-SSCP analysis

1993
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can ...
L. Varesco, V. Gismondi, R. James, M. Robertson, P. Grammatico, J. Groden, L. Casarino, L. De Benedetti, A. Bafico, L. Bertario, P. Sala, PONZ DE LEON, Maurizio, R. Sassatelli, G. Biasco, A. Allegretti, H. Aste, S. De Sanctis, C. Rossetti, MT Illeni, A. Sciarra, G. Del Porto, R. White, GB Ferrara   +22 more
openaire   +1 more source

Four novel germline mutations of the APC gene

Human Mutation, 1996
D, Wells, P, Chapman, J C, Landgrebe, K, Tsioupra, J D, Delhanty   +4 more
openaire   +2 more sources

Mutated APC Gene

Advances in Anatomic Pathology, 1994
openaire   +1 more source

Hepatoblastoma as a Result of APC Gene Mutation

Journal of Pediatric Gastroenterology and Nutrition, 2012
Maryna, Krawczuk-Rybak, Anna, Jakubiuk-Tomaszuk, Elzbieta, Skiba, Andrzej, Plawski   +3 more
openaire   +2 more sources

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

Cell Reports, 2021
Stanislau Yatskevich, Claudio Alfieri, Thomas Tischer   +2 more
exaly  

APC gene and presimptomatic genetic testing

2003
Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
openaire  

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation

Molecular Cell, 2021
Michael Ranes, Sebastian Guettler
exaly