Results 221 to 230 of about 156,482 (265)

Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene

Anatomical Science International, 2005
The adenomatous polyposis coli (Apc) gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. The Apc gene product (APC), basically a cytoplasmic protein, blocks cell cycle progression and plays crucial roles in development.
Takao, Senda, Atsushi, Shimomura, Akiko, Iizuka-Kogo   +2 more
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Purification of the Adenomatous Polyposis Coli (APC) Gene Product

Archives of Biochemistry and Biophysics, 1995
Mutation of the adenomatous polyposis coli (APC) gene is responsible for familial adenomatous polyposis and is an etiologic factor for digestive tract malignancies. Although the APC gene product (APC) is believed to play a role in growth suppression of colonocytes, the underlying mechanism is not clear. However, recent evidence does suggest that APC is
G, Bhattacharya, C A, Abraham, D M, Wildrick, B M, Boman   +3 more
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[The APC gene].

Nihon rinsho. Japanese journal of clinical medicine, 1996
The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in ...
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Association of the APC Gene Product with β-Catenin

Science, 1993
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was
B, Rubinfeld, B, Souza, I, Albert, O, Müller, S H, Chamberlain, F R, Masiarz, S, Munemitsu, P, Polakis   +7 more
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Brain metastases exhibit gross deletions of the APC gene

Brain Tumor Pathology, 2011
Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragment length polymorphism method ...
Pećina-Šlaus, Nives, Nikuševa Martić, Tamara, Zeljko, Martina, Bulat, Sandra   +3 more
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APC Gene Expression in Gastric Carcinoma: An Immunohistochemical Study

Applied Immunohistochemistry & Molecular Morphology, 2002
Gastric carcinoma is one of the most common malignancies worldwide, particularly in Japan and China. Inactivation of the adenomatous polyposis coli ( ) gene, a tumor suppressor gene, has been shown to play a significant role in the development of colorectal carcinoma, and it has been suggested that it may play a role throughout the digestive tract ...
A, Grace, D, Butler, M, Gallagher, R, Al-Agha, Y, Xin, M, Leader, E, Kay   +6 more
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Biallelic inactivation of the APC gene in hepatoblastoma.

Cancer research, 1995
Familial adenomatous polyposis (FAP) is an inherited disorder caused by germline mutation of the adenomatous polyposis coli (APC) gene. Increased risk of hepatoblastoma (HBL) in FAP kindreds has been reported. To determine whether inactivation of the APC gene plays a role in development of HBL, 13 sporadic infantile hepatic tumors were analyzed for ...
H, Kurahashi, K, Takami, T, Oue, T, Kusafuka, A, Okada, A, Tawa, S, Okada, I, Nishisho   +7 more
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The APC gene product and colorectal carcinogenesis.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1997
The adenomatous polyposis coli (APC) gene has been found to be mutated during the development of sporadic colorectal tumours as well as in familial adenomatous polyposis patients (FAP), mutations being somatic or germinal respectively. The gene product is truncated in the carboxyterminal region but the role of the APC protein in tumorigenesis is not ...
C, Bonneton, L, Larue, J P, Thiéry
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Mutations in the APC gene and their implications for protein structure and function

Current Opinion in Genetics & Development, 1995
An enormous number of germline and somatic mutations have been identified in the APC tumor suppressor gene. Nearly all of these mutations result in premature polypeptide chain termination, but the consequences to APC protein function are unknown. Recent advances, including the identification of an oligomerization domain, the localization of several ...
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APC gene and molecular diagnostics

2003
Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
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