Results 91 to 100 of about 113,876 (211)

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan.

Central Asian Journal of Global Health, 2013
Background: A large number of distinct mutations in the BRCA1 and BRCA2 genes have been reported worldwide, but little is known regarding the role of these inherited susceptibility genes in breast cancer risk among Kazakhstan women.
Ainur R. Akilzhanova, Bagdat Nyshanbekkyzy, Zhannur M. Nurkina, Ivan I. Shtephanov, Abay K. Makishev, Tasbolat A. Adylkhanov, Tolebay K. Rakhypbekov, Erlan M. Ramanculov, Kuvat T. Momynaliev   +8 more
doaj   +1 more source

Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1). [PDF]

Sci Rep, 2022
Berling-Ernst A, Yahiaoui-Doktor M, Kiechle M, Engel C, Lammert J, Grill S, Dukatz R, Rhiem K, Baumann FT, Bischoff SC, Erickson N, Schmidt T, Niederberger U, Siniatchkin M, Halle M.   +14 more
europepmc   +1 more source

How BRCA1 deficiency affects emergency granulopoeisis in cells [PDF]

, 2016
BRCA1 mutation carriers are predisposed to breast and ovarian cancer. Chemotherapy is a common treatment used in breast cancer patients. However, chemotherapy can cause damage to bone marrow.
Dhar, Shilpa
core   +2 more sources

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
A Lucassen, A Ziogras, AE Guttmacher, Caroline Seynaeve, Catharina E Jacobi, Cecile TM Brekelmans, Cees J Cornelisse, Christi J van Asperen, CJ Van Asperen, CJ Van Asperen, Collaborative Group on Hormonal Factors in Breast Cancer, D Ford, D Steinmann, D Thompson, DA Berry, DM Eccles, DM Eccles, EB Claus, EB Claus, Elly MM Krol-Warmerdam, FE Harrell Jr, G Parmigiani, Geertruida H de Bock, H Eerola, Jan GM Klijn, Jannet Blom, Johannes C van Houwelingen, JP Klein, KF Hoskins, KL Nathanson, O Visser, PD Pharoah, Peter Devilee, R Gershoni-Baruch, Rob AEM Tollenaar, RW Blamey, The Breast Cancer Linkage Consortium   +36 more
core   +8 more sources

Clinical characteristics of patients with Breast and / or Ovarian Cancer with mutations in the BRCA1 and BRCA2 genes in Córdoba, Argentina [PDF]

Rev Fac Cien Med Univ Nac Cordoba, 2022
Martin CA, Suárez Villasmil L, Sembaj A, Gomez Balangione F, Zunino S, Montes CDC, Borello A, Del Castillo A, Zeballos M, Rossi NT.   +9 more
europepmc   +1 more source

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. [PDF]

, 2018
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female.
Abe, Akalin, Alison E. Casey, Ankit Sinha, Asselin-Labat, Buenrostro, Cardiff, Cerami, Cheryl Arrowsmith, Chlebowski, Cox, Cox, Dalia Barsyte-Lovejoy, Daniel De Carvalho, Deugnier, Dos Santos, Edgar, Eirew, Eirew, Eisen, Erik Drysdale, Gary Bader, Gascard, Genevieve Deblois, Gu, Hal Berman, Heinz, Hennighausen, Herschkowitz, Hu, Hui Fang, Huston, Hyeyeon Kim, Ignatchenko, Jackson, Jennifer Cruickshank, Joshi, Joshi, Joshi, Julie Livingstone, Kaltenborn, Kauff, Kelsey, Kendrick, Kiechl, Kislinger, Koboldt, Kotsopoulos, Krueger, Kucera, Labarge, Li, Lim, Lim, Lin, Loenen, Lucas, Lydon, Marotti, Maruyama, Mathieu Lupien, McLean, Meissner, Merico, Michailidou, Michalak, Mohammed, Molyneux, Mona Shehata, Nguyen, Pal, Pathania, Paul C. Boutros, Paul Waterhouse, Pei, Pellacani, Pirashaanthy Tharmapalan, Rajat Singhania, Rama Khokha, Reimand, Rios, Rios, Rugg-Gunn, Ruth Isserlin, Schimanski, Shackleton, Shannon, Shehata, Shiah, Shu, Sigl, Smith, Smyth, Stefan Hofer, Stefan Knapp, Stingl, Storey, Stunnenberg, Subramanian, Swneke Bailey, Thomas Kislinger, Tiago Medina, Tomasetti, van Amerongen, Van Keymeulen, Van Keymeulen, Visvader, Wang, Wojtowicz, Wuidart, Yu-Jia Shiah, Zhang   +111 more
core   +2 more sources

Breast Cancer Gene, BRCA1 and BRCA2

Journal of Korean Breast Cancer Society, 2003
Hereditary predisposition to breast and ovarian cancer and responsible for autosomal-dominant transmission, most commonly due to germline mutations in BRCA1 and BRCA2 has been recognized for many years. Hereditary breast cancer is characterized by early age at onset, bilaterality, vertical transmission through both maternal and paternal lines, and ...
openaire   +1 more source

Testing for the breast cancer predisposition gene, BRCA1 [PDF]

BMJ, 1996
Each year there are 27 768 cases of breast cancer and 5100 cases of ovarian cancer in Britain.1 Most of these cases will be sporadic, in which genetic changes occur only within cancer cells. However, in rare instances a genetic change will have been inherited.
openaire   +2 more sources

Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry.

PLoS ONE, 2016
DNA methylation can mimic the effects of both germline and somatic mutations for cancer predisposition genes such as BRCA1 and p16INK4a. Constitutional DNA methylation of the BRCA1 promoter has been well described and is associated with an increased risk
Cameron M Scott, JiHoon Eric Joo, Neil O'Callaghan, Daniel D Buchanan, Mark Clendenning, Graham G Giles, John L Hopper, Ee Ming Wong, Melissa C Southey   +8 more
doaj   +1 more source