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Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024". [PDF]
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BRCA1 gene: function and deficiency
International Journal of Clinical Oncology, 2017The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1.
Miho, Takaoka, Yoshio, Miki
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Functions of the BRCA1 and BRCA2 genes
Current Opinion in Genetics & Development, 1998Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but ...
D, Bertwistle, A, Ashworth
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In-Silico Analyses of Nonsynonymous Variants in the BRCA1 Gene
Biochemical Genetics, 2021BReast CAncer gene 1 (BRCA1)-a tumor suppressor gene plays an important role in the DNA repair mechanism. Several BRCA1 variants perturb its structure and function, including synonymous and nonsynonymous single nucleotide polymorphisms (SNPs). In the present study, we performed in-silico analyses of nonsynonymous SNPs (nsSNPs) of the BRCA1 gene.
Sidra Arshad +4 more
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The dilemmas of a carrier of BRCA1 gene mutations
Patient Education and Counseling, 1998This article describes that the decision to be tested on carriership of hereditary cancer has consequences that are more far-reaching than a potential carrier can anticipate beforehand. The experiences of a 41 year old woman, carrier of a mutated BRCA1 gene, who shortly before her scheduled bilateral breast amputation, decided not to have surgery, are ...
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The BRCA1 and BRCA2 breast cancer genes
Current Opinion in Oncology, 1997Between 5% and 10% of breast cancer cases result from an inherited predisposition. The majority of hereditary forms of breast and ovarian cancer can be accounted for by mutations in two recently identified genes, BRCA1 and BRCA2. Inactivating mutations have been found throughout both genes, and the majority are predicted to result in truncated proteins.
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Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women
Journal of Cancer Research and Clinical Oncology, 2009BRCA1-interacting protein C-terminal helicase 1 (BRIP1) and zinc finger protein 350 (ZNF350) work with BRCA1 in tumor suppression procedures. Low penetrance variants of these three genes may jointly affect individuals' breast cancer susceptibility in general population.We focused on potentially functional single nucleotide polymorphisms (SNPs) in the ...
Xiang, Huo +10 more
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