Results 251 to 260 of about 115,309 (309)

Targeting poly(ADP-ribose) polymerase in metastatic prostate cancer: current landscape and future directions. [PDF]

Curr Opin Oncol
Shi X, Rifai S, Meher Z, Hussain A.
europepmc   +1 more source

At the Right Time: Temporal Precision in Personalised Medicine

Sociology of Health &Illness, Volume 48, Issue 4, May 2026.
ABSTRACT Personalised medicine was initially heralded as delivering ‘the right drug to the right patient at the right time’. Although molecular precision has dominated recent developments, the temporal dimension has remained underexplored. This paper examines how temporal precision is emerging as a defining feature of next‐generation precision medicine,
Dominik Hofmann, Elena Esposito
wiley   +1 more source

Advancing inducible gene-inactivation systems to explore synthetic lethality. [PDF]

NAR Cancer
Sánta ÁT, Gráf A, Vincze-Kontár K, Kovács K, Bóna B, Mórocz M, Kiss E, Haracska L.   +7 more
europepmc   +1 more source

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)—A Prospective Controlled Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 6, Page 1188-1199, May 2026.
ABSTRACT Objective To determine the effect of surgical menopause (risk‐reducing salpingo‐oophorectomy, RRSO) on sexual function and the modifying effects of HRT. Design Prospective observational study of women undergoing RRSO and age‐matched comparison group who retained their ovaries. Setting High‐risk clinics and general population.
Martha Hickey, Trevor Tejada‐Berges, Susan M. Domchek, Efrosinia O. Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg   +7 more
wiley   +1 more source

The Contribution of Genetic Modifiers to Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Pathogenic Variant Carriers. [PDF]

Cancers (Basel)
Cylwik D, Dwornik R, Białkowska K.
europepmc   +1 more source

Copy Number Amplification and c‐Myc Transcriptional Activation‐Mediated RNA‐Binding Protein MEX3A Promotes EGFR‐TKI Resistance in Non–Small‐Cell Lung Cancer

Thoracic Cancer, Volume 17, Issue 9, May 2026.
MEX3A, a pivotal RNA‐binding protein (RBP), which is activated by copy number amplification at the genomic level and regulated by the transcription factor c‐Myc at the transcriptional level, functions as a potential therapeutic target for overcoming TKI resistance in NSCLC. ABSTRACT Objective To investigate the functional role and activation mechanisms
Shi Xiling, Du Lin, Dai Jiali, Zhang Chen, Huang Ruohan, Zhang Chang, Guo Renhua, Li Jun   +7 more
wiley   +1 more source

Prevalence of Novel and Recurrent Pathogenic Variants in <i>BRCA</i> Genes in a Cohort of Iranian Hereditary Breast Cancer Patients. [PDF]

Adv Biomed Res
Sarmadi A, Haghjooy Javanmard S, Zeinalian M, Hosseinzadeh M, Tabatabaiefar MA.   +4 more
europepmc   +1 more source

Rs12516 A allele elevates the risk of colorectal cancer via functional CeRNA network of BDNF-AS, miR-4704-5p and BRCA1. [PDF]

BMC Cancer
Liu D, Fan Z, Zhang T, Li X, Ming C, Wu J, Lu X, Sun D.   +7 more
europepmc   +1 more source

Variant reclassification in cancer susceptibility genes and an updated variant spectrum of Turkish breast and colorectal cancer patients. [PDF]

Hum Genomics
Can ND, Akcay IM, Celik E, Ciftci C, Unal B, Agaoglu NB, Doganay HL, Dinler Doganay G.   +7 more
europepmc   +1 more source

Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency. [PDF]

Sci Rep
Nakamura Y, Daino K, Ishikawa A, Kakinuma S, Nishimura-Yano Y, Nagata K, Takabatake M, Nishimura M, Mashimo T, Inoue K, Imaoka T.   +10 more
europepmc   +1 more source