Results 231 to 240 of about 115,309 (309)

Clinical Features of Malignant Ovarian Germ Cell Tumors According to Demographic and Pathologic Characteristics

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Malignant ovarian germ cell tumors (MOGCTs) are aggressive cancers affecting mainly young women, in whom fertility preservation is important. Diagnosis is often delayed because early symptoms are non‐specific, leading to advanced disease or emergency surgery that may limit optimal staging and fertility‐sparing treatment. As
Jila Agah, Elham Navipour, Setareh Akhavan, Somaye Norouzi   +3 more
wiley   +1 more source

Genomic landscape and clinical impact of BRCA1/2 pathogenic variants in metastatic castration-resistant prostate cancer. [PDF]

NPJ Precis Oncol
Iida K, Urabe F, Matsui Y, Tashiro K, Yoshihara K, Urabe Y, Ishikawa T, Matsuzaki J, Kimura T, Saito Y.   +9 more
europepmc   +1 more source

Genotype–Phenotype Discordance in Cardiomyopathies: Pathophysiology, Clinical Expression, and Therapeutic Considerations

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Cardiomyopathies encompass a spectrum of myocardial disorders often attributed to underlying genetic mutations. However, genotype–phenotype discordance where the genetic profile does not align with the expected clinical presentation poses significant diagnostic, prognostic, and therapeutic challenges.
Abubakar Nazir, Atif Hussain Sarwar, Rameen Nazar, Sarim Hassan Shahab, Sumera Manan, Hafsa Rafique, Ahsan Talal Khan, Abdalhakim Shubietah, Syed Rafay Hussain Zaidi, Behram Khan   +9 more
wiley   +1 more source

Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver. [PDF]

Life (Basel)
Buyko EE, Perina EA, Sobakin DS, Tsyganov MM, Vasilchenko DV, Vtorushin SV, Ufandeev AA, Diksas EB, Kaidash OA, Hmelevskaya ES, Parochkina EV, Popov IA, Ivanov VV, Pekov SI, Udut EV.   +14 more
europepmc   +1 more source

KRAS Gene Variants rs712 and rs61764370 as Predictive Markers of Breast Cancer Susceptibility in a Bangladeshi Population: A Case‐Control Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background In women, breast cancer (BC) occurs more often than any other cancer worldwide and in Bangladesh. Genetic susceptibility, including functional polymorphisms affecting microRNA binding, may contribute to BC risk. This study aims to investigate the association between KRAS 3' UTR gene polymorphisms (rs712 and rs61764370) and BC risk ...
Taslia Afrose Eva, Mst. Mahfuja Tabassum Miti, Nusrat Zahan Nisha, Zarin Tasnim, Tithi Saha, Mayesha Khan, Nafisa Tabassum Moon, Md. Aminul Haque   +7 more
wiley   +1 more source

Editorial: Molecular studies and therapeutic approaches on BRCA-associated cancers. [PDF]

Front Mol Biosci
Bhat A, Wang X, Stephen P.
europepmc   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1487-1505, May 2026.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Frequency of Founder Mutations in <i>BRCA1</i> and <i>BRCA2</i> Genes in Hereditary Breast Cancers in Poland vs. Other Countries. [PDF]

Cancers (Basel)
Kulikowska B, Panasiuk B, Posmyk R.
europepmc   +1 more source

Limitations of Subgroup Safety Analyses for Drug–Drug Interaction Evaluation: Insights from the Talazoparib P‐gp Inhibitor Case

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Impact of concomitant medications (conmeds) on the safety of the investigational agent is often evaluated using subgroup analyses for safety events in patients who received the conmed versus those who did not. Here, we highlight the potential biases and inconclusive results that can arise from such analyses, using talazoparib and P ...
Diane Wang, Charvi Nanavati, Derek Z. Yang, Liza DeAnnuntis, Mohamed Elmeliegy   +4 more
wiley   +1 more source

Disease- and gene-specific deep learning for pathogenicity prediction of rare missense variants in cancer predisposition genes. [PDF]

BioData Min
Lee DB, Kang HU, Hwang KB.
europepmc   +1 more source