Results 271 to 280 of about 115,309 (309)

Analysis of the BRCA1 and BRCA2 genes in sporadic meningiomas

Genes, Chromosomes and Cancer, 1997
Several lines of evidence suggest a relationship between the occurrence of meningiomas and that of breast carcinomas: Both occur more frequently in women than in men, and a higher incidence of meningiomas has been observed in patients with a history of breast carcinoma.
M, Kirsch, J J, Zhu, P M, Black
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BRCA1 Gene Sequence Variation in Centenarians

Annals of the New York Academy of Sciences, 2001
Abstract: With the ample gene sequence information that has become available with the human genome project virtually completed, it has become possible to identify functional gene variants and their frequencies in elderly populations with different aging‐related characteristics.
J, Vijg, T, Perls, C, Franceschi, N J, van Orsouw   +3 more
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BRCA1 and BRCA2 - breast cancer susceptibility genes

Journal of Cancer Research and Clinical Oncology, 2000
Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations
W, Hofmann, P M, Schlag
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Males at‐risk for the BRCA1-gene, the psychological impact

Psycho‐Oncology, 1996
In recent literature the psychological impact of predictive DNA-testing for Hereditary Breast and Ovarian Cancer (HBOC) for male individuals at-risk has not been considered. We have observed that confrontation with the hereditary nature of breast/ovarian cancer does have a psychological impact on males at-risk.
de Wit, A. C. D., Tibben, A., Frets, P. G., Meijers-Heijboer, E. J., Devilee, P., Niermeijer, M. F.   +5 more
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BRCA1 Gene Mutation in Thymic Malignant Melanoma

The Annals of Thoracic Surgery, 2013
We present a patient with triple primary malignancies: thyroid cancer, ovarian cancer, and thymic malignant melanoma. We suspected that gene mutations were involved in the occurrence of these multiple primary cancers, and blood analysis revealed the presence of BRCA1 gene mutations.
Eun Jue, Yi, Jong Ho, Park, Hae Won, Lee, Soo Youn, Cho, Im Il, Na, Moon Chul, Kang   +5 more
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Gene Therapy for Breast and Ovarian Cancer with BRCA1

Breast Disease, 1998
As an initial step toward gene therapy for ovarian cancer, we conducted a Phase 1 trial to assess the pharmacokinetics and toxicity of intraperitoneal BRCA1sv retroviral vector therapy. Gene transfer and expression were documented by PCR, southern blot, RT-PCR and nuclease protection assays.
D L, Tait, R A, Jensen, J T, Holt, D H, Johnson, J, Gralow, M C, King   +5 more
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Premature Menopause in Patients with BRCA1 Gene Mutation

Breast Cancer Research and Treatment, 2006
This study was undertaken with regard to the gonadotropin theory of ovarian cancer advocated in the literature and was designed to disclose specific features of ovarian morphology in carriers of the BRCA1 gene mutation. We enrolled 171 patients and divided them into two groups: A (n=90)--operated for breast cancer (30 patients with and 60 without the ...
Izabella, Rzepka-Górska, Bogusław, Tarnowski, Anita, Chudecka-Głaz, Bohdan, Górski, Dorota, Zielińska, Aleksandra, Tołoczko-Grabarek   +5 more
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Novel complex genomic rearrangement of the BRCA1 gene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008
Initial BRCA1 and BRCA2 analyses conducted in breast and ovarian cancer families were focused on identification of mutations in coding sequences and splicing sites of the genes. Large genomic rearrangements as well as mutations in promoter or untranslated regions have been missed by standard detection strategies.
Michal, Zikan, Petr, Pohlreich, Jana, Stribrna, Zdenek, Kleibl, David, Cibula   +4 more
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Ovarian Cancer Gene Therapy with BRCA1–An Overview

2003
The human breast and ovarian cancer susceptibility gene BRCA1 is a tumorsuppressor gene which is mutated and lost in hereditary breast and ovarian cancer, and has both alleles mutated in approximately 10-15% of cases of sporadic ovarian cancer. Studies of chromosome loss in ovarian cancer show that at least one allele of the BRCA1 gene is lost or ...
P S, Obermiller, J T, Holt
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Cloning and characterization of the BRCA1 gene

2012
Approximately 10% of all American women develop breast cancer during their lifetimes. A genetic trait which is passed through families in an autosomal dominant fashion is responsible for 5% to 10% of the cases. Women who care a breast cancer susceptibility gene have an 85% lifetime risk of breast cancer and also often have an increased risk of ...
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