Results 141 to 150 of about 44,727 (269)

Genes Involved in the Cisplatin Response of BRCA2 Cancers

, 2012
Breast and ovarian cancers are two of the most prevalent types of cancer in women and kill over 55,000 people annually in the US alone. A number of these cases are deficient in BRCA1 or 2, tumor suppressor genes involved in DNA repair.
Rose, Juliana Mary
core  

BRCA1 and BRCA2mutations in breast cancer patients from Venezuela

Biological Research, 2012
A sample of 58 familial breast cancer patients from Venezuela were screened for germline mutations in the coding sequences and exon-intron boundaries of BRCA1 (MIM no. 113705) and BRCA2 (MIM no.
Karlena Lara, Nigmet Consigliere, Jorge Pérez, Antonietta Porco   +3 more
doaj  

BRCA2 Gene [PDF]

, 2020
openaire   +1 more source

Comparisons between HRM screening and sequencing of BRCA1 and BRCA2 genes.

, 2012
Comparisons between HRM screening and sequencing of BRCA1 and BRCA2 genes.
Edmond Siu Kwan Ma (136398), Dee W. West (136393), Enders Kai On Ng (136378), Chris Lei Po Wong (136381), James M. Ford (136395), Ava Kwong (52115), Fian Bic Fai Law (136383), Tommy Au (136386), Hong Nei Wong (136388), Allison W. Kurian (136390)   +9 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Prevalence and spectrum of germline BRCA1 and BRCA2 mutations in multiethnic cohort of breast cancer patients in Brunei Darussalam.

PLoS ONE
This is the first genetic study of its kind in Brunei Darussalam. BRCA1 and BRCA2 genes are the most well-known and well described predictors of hereditary breast cancer due to their clinical importance.
Siti Nur Idayu Matusin, Nuramalina Mumin, Hazirah Zainal Abidin, Fatin Nurizzati Mohd Jaya, Zen Huat Lu, Mas Rina Wati Haji Abdul Hamid   +5 more
doaj   +1 more source

BRCA1/2 mutation spectrum in Armenian patients with breast and ovarian cancers

Сибирский онкологический журнал
The aim of the study was to compare the spectra of pathogenic BRCA1 and BRCA2 variants in patients with hereditary breast cancer (BC) and ovarian cancer (OC) from two groups of ethnic Armenians: Yerevan and cities of southern Russia.Material and Methods.
Y. V. Belysheva, E. K. Bakaeva, A. R. Venina, A. A. Romanko, G. A. Raskin, A. P. Sokolenko, E. N. Suspitsin, A. A. Avetisyan, S. V. Orlov, E. N. Imyanitov   +9 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

BRCA2 as a Low-Penetrance Cancer Gene [PDF]

JNCI: Journal of the National Cancer Institute, 1996
openaire   +2 more sources

The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer

, 2002
Background: In sporadic ovarian cancer, we have previously reported allele loss at D6S193 (62%) on chromosome 6q27, which suggested the presence of a putative tumour suppressor gene.
Liu, Y, Phillippa Dodds, Charnock, FML, Dodds, P, Dunham Ian, Liu Ying, Wells R Spencer, Gracy Emilion, Ganesan Trivadi S, Beck, Stephan, Charnock, F Mark L, Emilion, G, Stephan Beck, Mungall, Andrew J, Ian Dunham, F Mark L Charnock, Wells, RS, Ganesan, TS, Emilion, Gracy, Dunham, I, Dodds Phillippa, Beck Stephan, Emilion Gracy, Wells, R Spencer, Dunham, Ian, Mungall Andrew J, Andrew J Mungall, Ying Liu, R Spencer Wells, Beck, S, Liu, Ying, Mungall, AJ, Trivadi S Ganesan, Charnock F Mark L, Dodds, Phillippa, Ganesan, Trivadi S   +35 more
core   +1 more source