Results 161 to 170 of about 44,727 (269)
Revista Colombiana de Obstetricia y Ginecología, 2015 Objetivo: describir variantes de secuencia en los genes BRCA1 y BRCA2 en una muestra de pacientes colombianas con historia personal o familiar de cáncer de mama sugestiva de riesgo genético. Materiales y métodos: serie de casos compuesta por 67 pacientes
Juan Felipe Arias-Blanco +9 more
doaj
Food Science &Nutrition, Volume 14, Issue 6, June 2026.TSF and Rg3 demonstrate significant cardioprotective effects against DOX‐induced cardiotoxicity (DIC) by mitigating oxidative stress, inflammation, and apoptosis while preserving mitochondrial function. These findings provide novel insights into the clinical relevance of TSF and Rg3 in the management of DIC.
Linlin Liu +5 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.Simultaneous treatment with lutein and cisplatin enhances oxidative DNA damage in breast cancer cells (MCF‐7 and MDA‐MB‐231) and promotes apoptosis specifically in MDA‐MB‐231 cells, while modulating DNA repair and damage response genes across cell types. Additionally, the combination increases cytotoxicity in HUVECs.
Funda Demirtas Korkmaz +2 more
wiley +1 more source
[Evaluation of variants of unknown significance in the BRCA2 gene].
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 2012 Endogenous processes and exogenous agents cause constant DNA damage. DNA double-strand breaks are among the most serious types of damage. They are mainly repaired by homologous recombination, where the BRCA2 protein plays a dominant role. Heterozygous germline BRCA2 mutations predispose to breast, ovarian, pancreatic and other types of cancer.
M, Heczková +5 more
openaire +1 more source
Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.This graphical abstract summarizes the major immune‐evasion mechanisms that limit immunotherapy efficacy in ovarian cancer peritoneal metastasis. Peritoneal dissemination is shaped by impaired antigen visibility, coordinated immune‐evasion modules within ascites and multicellular spheroids, checkpoint‐driven T‐cell exhaustion, suppressive tumor ...
Xiaodong Wang +8 more
wiley +1 more source
Genomic rearrangements in BRCA1 and BRCA2: a literature review
Genetics and Molecular Biology, 2009 Women with mutations in the breast cancer genes BRCA1 or BRCA2 have an increased lifetime risk of developing breast, ovarian and other BRCA-associated cancers.
Ingrid Petroni Ewald +5 more
doaj
Journal of Genetic Counseling, Volume 35, Issue 3, June 2026.Abstract Genetic testing is increasingly used to identify people at increased risk for future health conditions. As clinical practice guidelines and science evolve, undergoing repeat genetic counseling and potentially repeat testing may be beneficial to receive updated recommendations.
Savanna Kerstiens +6 more
wiley +1 more source