Results 181 to 190 of about 72,678 (220)

Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer

Breast Cancer Research and Treatment, 2005
We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous ...
Tomasz, Sliwinski, Renata, Krupa, Ireneusz, Majsterek, Jan, Rykala, Agnieszka, Kolacinska, Zbigniew, Morawiec, Jozef, Drzewoski, Marek, Zadrozny, Janusz, Blasiak   +8 more
openaire   +3 more sources

Analysis of the BRCA1 and BRCA2 genes in sporadic meningiomas

Genes, Chromosomes and Cancer, 1997
Several lines of evidence suggest a relationship between the occurrence of meningiomas and that of breast carcinomas: Both occur more frequently in women than in men, and a higher incidence of meningiomas has been observed in patients with a history of breast carcinoma.
M, Kirsch, J J, Zhu, P M, Black
openaire   +2 more sources

The BRCA1 and BRCA2 breast cancer genes

Current Opinion in Oncology, 1997
Between 5% and 10% of breast cancer cases result from an inherited predisposition. The majority of hereditary forms of breast and ovarian cancer can be accounted for by mutations in two recently identified genes, BRCA1 and BRCA2. Inactivating mutations have been found throughout both genes, and the majority are predicted to result in truncated proteins.
openaire   +2 more sources

Genomic organization and expression of the mouse Brca2 gene

Mammalian Genome, 2002
A mutation of the Brca2 gene product is responsible for a large proportion of the inherited breast cancers. Here, we have demonstrated that the mouse Brca2 gene is composed of 27 exons and 26 introns, spanning approximately 48 kbp, almost all intron-exon junctions being classical.
Callens, Nathalie, Dumont, Martine, Begue, Agnès, Van Lint, Carine, Baert, Jean-Luc, Simard, Jacques, De Launoit, Yvan   +6 more
openaire   +4 more sources

BRCA1 and BRCA2 - breast cancer susceptibility genes

Journal of Cancer Research and Clinical Oncology, 2000
Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations
W, Hofmann, P M, Schlag
openaire   +2 more sources

BRCA2 gene mutations and coagulation-associated biomarkers

Thrombosis and Haemostasis, 2016
SummaryThromboembolic events are the second cause of death in cancer patients, although the mechanisms underlying this increased thromboembolic risk remain unclear. The aims of this study were to examine whether BRCA2 gene mutations may modify the circulating levels of thrombocoagulation biomarkers and whether breast cancer development may influence ...
Pedro, Perez-Segura, José J, Zamorano-León, Daniel, Acosta, Juana María, Santos-Sancho, Javier, Modrego, Trinidad, Caldés, Miguel, de la Hoya, Eduardo, Díaz-Rubio, Isabel, Díaz-Millán, Natalia, de Las Heras, Luis Alfonso, Rico Zalba, Vicente, Lahera, Olle, Melander, Antonio, López Farré   +13 more
openaire   +2 more sources

Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes

International Journal of Gynecological Cancer, 2020
Several genes associated with hereditary ovarian cancer have been discovered as a result of the work done with next generation sequencing. It is estimated that approximately 23% of ovarian carcinomas have a hereditary predisposition. The most common hereditary condition is represented by germline mutations in BRCA1 or BRCA2 genes that account for 20-25%
Pietragalla A., Arcieri M., Marchetti C., Scambia G., Fagotti A.   +4 more
openaire   +4 more sources

Mutation analysis in the BRCA2 gene in primary breast cancers

Nature Genetics, 1996
Breast cancer, one of the most common and deleterious of all diseases affecting women, occurs in hereditary and sporadic forms. Hereditary breast cancers are genetically heterogeneous; susceptibility is variously attributable to germline mutations in the BRCA1 (ref. 1), BRCA2 (ref. 2), TP53 (ref.
Y, Miki, T, Katagiri, F, Kasumi, T, Yoshimoto, Y, Nakamura   +4 more
openaire   +2 more sources

Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing

Molecular Medicine Today, 1997
Two cancer susceptibility genes, BRCA1 on chromosome 17q12-21 and BRCA2 on chromosome 13q12-13, are thought to be responsible for approximately 80% of families containing multiple cases of early-onset female breast cancer. Germline mutations of BRCA1 are also associated with ovarian cancer and mutations of BRCA2 are associated with an increased risk of
S A, Gayther, B A, Ponder
openaire   +2 more sources

RNA-based analysis of BRCA1 and BRCA2 gene alterations

Cancer Genetics and Cytogenetics, 2006
Alterations in BRCA1 and BRCA2 genes account for a large proportion of hereditary breast and ovarian cancers. Mutations and variants of unknown pathological significance have been identified in both genes; however, most of them have been studied only at the genomic level, and their effect on mRNA expression remains unknown.
Fabrizia, Bonatti, Chiara, Pepe, Mariella, Tancredi, Grazia, Lombardi, Paolo, Aretini, Elisa, Sensi, Elisabetta, Falaschi, Giovanna, Cipollini, Generoso, Bevilacqua, Maria Adelaide, Caligo   +9 more
openaire   +2 more sources