Results 191 to 200 of about 1,715,615 (239)

Co-occurring rare germline DNA repair gene variants in BRCA1/BRCA2 implicated hereditary breast cancer families. [PDF]

NPJ Breast Cancer
Alenezi WM, Recio N, Fierheller CT, Serruya C, Revil T, Mes-Masson AM, Provencher D, Greenwood CMT, Ragoussis J, Tonin PN.   +9 more
europepmc   +1 more source

Distinct functions of mammalian RAD51 paralogs in genome maintenance. [PDF]

Biochem Soc Trans
Dwivedi HK, Bhattacharya D, Kadupatil S, Nagaraju G.   +3 more
europepmc   +1 more source

The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial. [PDF]

Cancer Prev Res (Phila)
Senter L, Hovick S, Notestine R, Norden L, Benny N, Phillips S, Willoughby A, Pyatt R, Agnese D, Mak JS, DePersia A, Colonna SV, Maxwell WF, Kohlmann W, Spaeth EL, Gordon O, Thull D, Brock GN, Webb A, Smith RM, Toland AE.   +20 more
europepmc   +1 more source

Clinicopathological and molecular study of two unique cases with microglandular and acinic cell-like breast carcinoma. [PDF]

Histopathology
Liu L, Huang Y, Jia S, Du P, Zhang R, Cheng L, Wang Y.   +6 more
europepmc   +1 more source

Breast cancer risk genes affecting individual radiosensitivity. [PDF]

Sci Rep
Vogel RKG, Amann N, Kassem TZ, Gaß P, Mayo T, Woltereck F, Hack CC, Fietkau R, Corradini S, Distel L, Kuhlmann LCF.   +10 more
europepmc   +1 more source

Genomic Landscape of Early-Onset Colorectal Cancer: A Comparative Analysis With Average-Onset Metastatic Colorectal Cancer in a Real-World NGS Cohort. [PDF]

JCO Precis Oncol
Shin JE, Lee E, Ha SY, Lim SH, Cho YB, Park YS, Lee J, Kim ST.   +7 more
europepmc   +1 more source

VAF-tumor content graph: a simple visual framework for interpreting hereditary cancer variants and supporting genetic counseling in tumor-only sequencing. [PDF]

J Hum Genet
Kashima M, Tsubamoto H, Ueda T, Kinjo C, Okada C, Muroi Y, Ueda M, Otsuki T, Kataoka K, Nagahashi M, Matsuda I, Sawai H, Kijima T, Miyazaki A.   +13 more
europepmc   +1 more source

Updated Testing Sensitivities and Variants of Uncertain Significance in CanRisk

Easton DF, Carver T, Ficorella L, Hanson H, Snape K, Tsoulaki O, Usher-Smith JA, Archer S, Tischkowitz M, Antoniou A.   +9 more
europepmc   +1 more source

Integrating enriched case data from national laboratory testing with population-based case-control analyses: a novel statistical likelihood-ratio methodology for PS4 applied to 325,345 breast cancer cases and 671,006 controls

Allen S, Rowlands CF, Garrett A, Couch F, Richardson ME, Pesaran T, Pethick J, Lavelle K, McRonald F, Vernon S, Torr B, Loong L, Aungraheeta R, Durkie M, Burghel GJ, Callaway A, Robinson R, Field J, Frugtniet B, Palmer-Smith S, Grant J, Pagan J, McDevitt T, Snape K, Hanson H, McVeigh T, Loveday C, Jones M, Hardy S, Turnbull C, CanVIG-UK.   +30 more
europepmc   +1 more source

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Functions of the BRCA1 and BRCA2 genes

Current Opinion in Genetics & Development, 1998
Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but ...
D, Bertwistle, A, Ashworth
openaire   +2 more sources