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Mutations of the BRCA2 gene in ovarian carcinomas.
Cancer research, 1996Inherited mutations in the recently discovered BRCA2 gene are believed to be responsible for a significant fraction of early-onset hereditary breast cancers. Unlike BRCA1, however, which confers a high risk to both breast and ovarian cancer, the incidence of ovarian cancer appears to be much lower In BRCA2-linked families, causing uncertainty as to the
H, Takahashi +16 more
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Mutations in the BRCA2 gene in hepatocellular carcinomas.
Cancer research, 1996To investigate whether the BRCA2 gene plays a role in carcinogenesis of hepatocellular carcinomas or pancreatic cancers in view of frequent losses of heterozygosity on chromosome 13q12-13 in those tumors, we screened the entire coding region of this gene for mutations in 60 hepatocellular carcinomas and 36 pancreatic cancers. No alteration was found in
T, Katagiri, Y, Nakamura, Y, Miki
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Genetic testing for BRCA1 and BRCA2 genes
The Nurse Practitioner, 2014Cathy R, Kessenich +2 more
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DSS1 and ssDNA regulate oligomerization of BRCA2
Nucleic Acids Research, 2020Fei Guo, Wolf-Dietrich Heyer, Jie Liu
exaly
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
Molecular Cell, 2023Simon J Boulton, Roopesh Anand
exaly
Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2
Molecular Cell, 2022Lepakshi Ranjha +2 more
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Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
Nucleic Acids Research, 2017Humberto Sanchez +2 more
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
Molecular Cell, 2019Richard O Adeyemi +2 more
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