Germline genetic profiling utilizing multigene panel testing in Jordanian patients with pancreatic cancer: a comprehensive cancer center experience. [PDF]
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Hereditary ovarian cancer in women with African ancestry: a scoping review. [PDF]
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Germline <i>BRCA</i> testing in routine clinical practice: a single-center experience. [PDF]
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Prevalence and spectrum of homologous recombination repair mutations in patients with metastatic prostate cancer from India. [PDF]
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Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models. [PDF]
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Metabolomic-driven prediction of the mutational status of healthy individuals with a family history of hereditary breast and ovarian cancer syndrome: the HRRmet study. [PDF]
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Ensemble Machine Learning on Bulk RNA-Seq Identifies 17-Gene Signature Predicting Neoadjuvant Chemotherapy Response in Breast Cancer. [PDF]
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Characteristics of Germline and Somatic Mutations of DNA Repair Genes in Korean Men with Prostate Cancer. [PDF]
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Functions of the BRCA1 and BRCA2 genes
Current Opinion in Genetics & Development, 1998Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but ...
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