Results 171 to 180 of about 44,727 (269)

Molecular architecture of the tumor microenvironment caused by <i>BRCA1</i> and <i>BRCA2</i> somatic mutations in human lung adenocarcinoma. [PDF]

Elife
Liao G, Yang X, Liu Q, Nan S, Liu Y, Li J, Huang S, Ning W, Qin X, Xu G.   +9 more
europepmc   +1 more source

BRCA2 Gene Mutation Negative [PDF]

, 2020
openaire   +1 more source

Sublineage‐Specific A45S Polymorphism Alters the Biological Function of the Human Papillomavirus 11 E7 Protein

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT The E7 oncoprotein of human papillomavirus (HPV) plays a crucial role in viral pathogenesis and replication. Although it is generally highly conserved across HPV genotypes, naturally occurring E7 variants can display functional differences that may affect viral persistence, oncogenic potential, and host cellular responses.
Zsolt Barnabás Éles, Leila Rahmani, Eszter Gyöngyösi, Krisztina Szarka, István Rebenku, György Veress, Tamás Major, József Kónya, Anita Szalmás   +8 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

The Performance of <i>In Silico</i> Prediction Tools for Variant Curation in a Panel of Cancer Genes. [PDF]

Hum Mutat
Nelson N, Niaz A, Fairfax K, Bryan TM, Lucas S, Dickinson J.   +5 more
europepmc   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Identification of <i>BRCA2</i> Likely Germline Pathogenic Variants in Patients with Multiple Primary Lung Adenocarcinomas. [PDF]

Oncol Res
Quoc Tran D, Takeda M, Sugihara E, Tsukamoto T, Hoshikawa Y, Mizutani Y, Shiogama K, Asai N, Niimi A, Sumitomo M, Saya H, Suzuki M.   +11 more
europepmc   +1 more source

Germline BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India

, 2018
Anurag Mehta,1 Smreti Vasudevan,2 Sanjeev Kumar Sharma,1 Dushyant Kumar,1 Manoj Panigrahi,1 Moushumi Suryavanshi,1 Garima Gupta2 1Department of Laboratory and Transfusion Services, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110085 ...
Kumar D, Sharma SK, Mehta A, Gupta G, Panigrahi M, Vasudevan S, Suryavanshi M   +6 more
core  

Australian Adaptation of Resources to Communicate Hereditary Cancer Risk With Family Members

Psycho-Oncology, Volume 35, Issue 6, June 2026.
ABSTRACT Background Communicating genetic test results within families can facilitate cascade testing that informs cancer prevention and surveillance. Researchers at the University of Washington, USA, developed a public website called ConnectMyVariant to support family communication of genetic test results.
Luna Rodriguez Grieve, Kirsty Galpin, Heather Thorne, Sarah Powell, Nicci Bartley, Haryana M. Dhillon, Brian Shirts, Joanne Shaw   +7 more
wiley   +1 more source

Socioeconomic and Demographic Factors in Genetic Testing Utilization Among Advanced Prostate Cancer Patients

The Prostate, Volume 86, Issue 8, Page 941-948, June 2026.
ABSTRACT Purpose Germline genetic testing in patients with advanced prostate cancer (PCa) is underutilized and hypothesized to be impacted by socioeconomic and demographic factors. This single institution, retrospective study assessed the association of income and social vulnerability with genetic referrals and testing.
Alexandra T. Skowron, Karen Childers, Courtney M. Rose, Kyle C. McElyea, Avery K. Supernois, Yousuf Hussain, Mohammed Baseer, Sunita Ghosh, Clara Hwang   +8 more
wiley   +1 more source