Results 131 to 140 of about 1,715,615 (239)

BRCA2 Gene [PDF]

, 2020
openaire   +1 more source

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer

MedComm, Volume 7, Issue 10, October 2026.
Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu   +3 more
wiley   +1 more source

Prevalence and spectrum of germline BRCA1 and BRCA2 mutations in multiethnic cohort of breast cancer patients in Brunei Darussalam.

PLoS ONE
This is the first genetic study of its kind in Brunei Darussalam. BRCA1 and BRCA2 genes are the most well-known and well described predictors of hereditary breast cancer due to their clinical importance.
Siti Nur Idayu Matusin, Nuramalina Mumin, Hazirah Zainal Abidin, Fatin Nurizzati Mohd Jaya, Zen Huat Lu, Mas Rina Wati Haji Abdul Hamid   +5 more
doaj   +1 more source

BRCA1/2 mutation spectrum in Armenian patients with breast and ovarian cancers

Сибирский онкологический журнал
The aim of the study was to compare the spectra of pathogenic BRCA1 and BRCA2 variants in patients with hereditary breast cancer (BC) and ovarian cancer (OC) from two groups of ethnic Armenians: Yerevan and cities of southern Russia.Material and Methods.
Y. V. Belysheva, E. K. Bakaeva, A. R. Venina, A. A. Romanko, G. A. Raskin, A. P. Sokolenko, E. N. Suspitsin, A. A. Avetisyan, S. V. Orlov, E. N. Imyanitov   +9 more
doaj   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Impact of gene patents and licensing practices on access to genetic testing for inherited susceptibility to cancer: comparing breast and ovarian cancers with colon cancers.

, 2010
Genetic testing for inherited susceptibility to breast and ovarian cancer can be compared with similar testing for colorectal cancer as a "natural experiment." Inherited susceptibility accounts for a similar fraction of both cancers and genetic testing ...
DeRienzo, Christopher, Cook-Deegan, Robert, Chandrasekharan, Subhashini, Carbone, Julia, Conover, Christopher, Heaney, Christopher   +5 more
core   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

BRCA2 Gene Mutation [PDF]

, 2020
openaire   +1 more source

BRCA2 as a Low-Penetrance Cancer Gene [PDF]

JNCI: Journal of the National Cancer Institute, 1996
openaire   +2 more sources

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classificationResearch in context

EBioMedicine
Summary: Background: Pathogenic germline variants in certain genes are associated with somatic tumour mutation signatures. The use of somatic tumour mutation data has the potential to improve the identification of true pathogenic variants but remains ...
Cristina Fortuno, Jia Zhang, Lambros T. Koufariotis, Georgina Hollway, Scott Wood, John V. Pearson, Peter T. Simpson, Sunil R. Lakhani, Amy E. McCart Reed, Heather Thorne, G Bruce Mann, Anita R. Skandarajah, Lisa Devereux, Qihong Zhao, Dilanka L. De Silva, Geoffrey J. Lindeman, Paul Waring, Paul A. James, Ian Campbell, Amanda B. Spurdle, Nicola Waddell   +20 more
doaj   +1 more source