Results 21 to 30 of about 900,077 (291)

Nucleolar dominance and ribosomal RNA gene silencing [PDF]

Current Opinion in Cell Biology, 2010
Nucleolar dominance is an epigenetic phenomenon that occurs in genetic hybrids and describes the expression of 45S rRNA genes inherited from one progenitor due to the silencing of the other progenitor's rRNA genes. Nucleolar dominance is a manifestation of rRNA gene dosage control, which also occurs in non-hybrids, regulating the number of active rRNA ...
Sarah, Tucker, Alexa, Vitins, Craig S, Pikaard   +2 more
openaire   +2 more sources

Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]

, 2003
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Billingsley, G., Graw, Jochen, Heon, E., Illig, T., Klopp, N., Rudolph, G., Wjst, M.   +6 more
core   +1 more source

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank

Scientific Reports, 2023
We recently devised continuous “sex-scores” that sum up multiple quantitative traits, weighted by their respective sex-difference effect sizes, as an approach to estimating polyphenotypic “maleness/femaleness” within each binary sex.
Daniel E. Vosberg, Zdenka Pausova, Tomáš Paus   +2 more
doaj   +1 more source

Day-to-day dynamics of commensal Escherichia coli in Zimbabwean cows evidence temporal fluctuations within a host-specific population structure [PDF]

, 2017
To get insights into the temporal pattern of commensal Escherichia coli populations, we sampled the feces of four healthy cows from the same herd in the Hwange District of Zimbabwe daily over 25 days. The cows had not received antibiotic treatment during
Andremont, Antoine, Caron, Alexandre, Chatel, Jérémie, Clermont, Olivier, Couffignal, Camille, D'Humières, Camille, Denamur, Erick, Massot, Méril, Mentré, France, Plault, Nicolas   +9 more
core   +1 more source

Gene Therapy for Autosomal Dominant Disorders of Keratin [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2005
Dominant mutations that interfere with the assembly of keratin filaments cause painful and disfiguring epidermal diseases like pachyonychia congenita and epidermolysis bullosa simplex. Genetic therapies for such diseases must either suppress the production of the toxic proteins or correct the genetic defect in the chromosome.
Lewin, Alfred S., Glazer, Peter M., Milstone, Leonard M.   +2 more
openaire   +2 more sources

Dominant constraints on the evolution of rhythmic gene expression

Computational and Structural Biotechnology Journal, 2022
AbstractAlthough the individual transcriptional regulators of the core circadian clock are distinct amongst different organisms, the autoregulatory feedback loops they form are conserved. This unified design principle explains how daily physiological activities oscillate across species.
Yang Cheng, Yuhao Chi, Linying Sun, Guang-Zhong Wang   +3 more
openaire   +3 more sources

A Joint Segregation Analysis of the Inheritance of Fertility Restoration for Cytoplasmic Male Sterility in Pepper

Journal of the American Society for Horticultural Science, 2019
A cytoplasmic male sterility (CMS) system is one of the most efficient ways to produce F1 hybrid seeds in pepper (Capsicum annuum). Restorer-of-fertility (Rf) genes are a critical component within the CMS/Rf system.
Bingqiang Wei, Lanlan Wang , Paul W. Bosland, Gaoyuan Zhang, Ru Zhang   +4 more
doaj   +1 more source

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]

, 2012
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean, Bau, Bau, Bender, Bender, Botta, Chunhui Hou, Cook, Cui, de Gennes, Dekker, Dorier, Dostie, Drissen, Duan, Farrell, François Képès, Fraser, Hadjur, Handoko, Hou, Hou, Ivan Junier, Junier, Kalhor, Kiefer, Kim, Krivega, Kurukuti, Langowski, Lee, Lieberman-Aiden, Marenduzzo, Mateos-Langerak, Mukhopadhyay, Murrell, Ong, Palstra, Phillips, Ragoczy, Reuillon, Rosa, Rousseau, Ryan K. Dale, Schoenfelder, Sexton, Sexton, Simonis, Song, Song, Splinter, Stamatoyannopoulos, Strick, Tolhuis, Vakoc, Wallace, Yaffe   +56 more
core   +6 more sources

Allele-specific silencing of dominant disease genes [PDF]

Proceedings of the National Academy of Sciences, 2003
Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a linked single-nucleotide polymorphism
Victor M, Miller, Haibin, Xia, Ginger L, Marrs, Cynthia M, Gouvion, Gloria, Lee, Beverly L, Davidson, Henry L, Paulson   +6 more
openaire   +2 more sources

Genetic Analysis and Molecular Mapping of an All-Stage Stripe Rust Resistance Gene in Triticum aestivum-Haynaldia villosa Translocation Line V3

Journal of Integrative Agriculture, 2013
Triticum aestivum-Hayaldia villosa translocation line V3 has shown effective all-stage resistance to the seven dominant pathotypes of Puccinia striiforms f. sp. tritici prevalent in China. To elucidate the genetic basis of the resistance, the segregating
Lu HOU, Dong-fang MA, Mao-lin HU, Miao-miao HE, Yan LU, Jin-xue JING   +5 more
doaj   +1 more source