Results 191 to 200 of about 71,732 (246)

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific. [PDF]

Cell Stress Chaperones
Rabenius A, Salim I, Lindström H, Pak A, Aktay S, Vihervaara A.   +5 more
europepmc   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data. [PDF]

Brain Behav
Xiong J, Hagenauer MH, Rhoads CA, Flandreau E, Rempel-Clower N, Hernandez E, Nguyen DM, Saffron A, Duan T, Watson S, Akil H.   +10 more
europepmc   +1 more source

Oral Angiolymphoid Hyperplasia With Eosinophilia Exhibiting Cutaneous‐Type Histopathologic Features: Clinical Regression Following Hormonal Withdrawal and a 50‐Year Review

Journal of Cutaneous Pathology, EarlyView.
Case report of a 30‐year‐old female. Asymptomatic, red‐purple hyperplastic lesion extending from teeth 21 to 25, with bleeding upon manipulation. Differential diagnosis included: inflammatory gingival hyperplasia, plasma cell gingivitis, leukemia, and Wegener's granulomatosis.
Pedro Vinícius Santos de Jesus, Louise Cristina Santos, Gilberth Tadeu Dos Santos Aciole, John Lennon Silva Cunha, Nicole Lonni, Matheus Antoni da Silva Costa, Elena Riet Correa Rivero, Rogério Gondak, Ricardo Luíz Cavalcanti de Albuquerque‐Júnior   +8 more
wiley   +1 more source

Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation. [PDF]

Mol Metab
Zimmermann T, Bleymehl K, Haebel P, Perens J, Roostalu U, Hecksher-Sørensen J, Doerr J, Jarosch S, Lam D, Klein H, Pekcec A, Chehimi SN, Crist RC, Reiner BC, Hayes MR, Augustin R.   +15 more
europepmc   +1 more source

Evidence‐ and consensus‐based guideline on lichen sclerosus

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The German‐language, consensus‐ and evidence‐based S3 guideline on lichen sclerosus (LS) was developed based on the European “EuroGuiDerm Guideline on lichen sclerosus” under the leadership of the German Dermatological Society (DDG) and the German Society for Gynecology and Obstetrics (DGGG).
Gudula Kirtschig, Linn Woelber, Andreas Günthert, Karl Becker, Alexandra Ciresa‐König, Bettina Fischer, Susanne Fricke‐Otto, Claudia Günther, Christine Hirchenhain, Narayani Helga Köllmann, Alexander Kreuter, Bartosz Malisiewicz, Felix Neis, Dan mon O'Dey, Hagen Ott, Martin Promm, Regina Renner, Anne‐Rose Schardt, Ines Schweizer, Raimund Stein, Jan Ter‐Nedden, Gerda Trutnovsky, Agnes Wand, Gerhard Weyandt, Ricardo N. Werner, Maria Kinberger   +25 more
wiley   +1 more source

SLC46A1 deficiency-mediated folate restriction suppresses colorectal cancer progression through epigenetic-transcriptional reprogramming. [PDF]

Cell Death Dis
Zhou Y, Liu Y, Liu Y, Che C, Zhao Y, Yu J, Li X, Li A, Chen S, Wang H, Zhou M, Liu D, He W, Wang Z, Han H, Wang X, Lu Y, Wu K, Zhao X.   +18 more
europepmc   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Glycyrrhiza polysaccharide attenuates <i>Neospora caninum</i>-induced intestinal epithelial cell damage by the C/EBPβ/IL-17/TNF signaling pathway. [PDF]

Front Vet Sci
Wang S, Meng S, An Y, Qian W, Ma Y, Guo S, Zhang C.   +6 more
europepmc   +1 more source