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Expression of the C-Fos Gene During Differentiation

1987
Retroviruses cause tumors in experimental animals via a number of diverse mechanisms. One group of viruses induces transformation by introduction of a viral gene (v-onc) derived from a normal cellular gene (c-onc) (1–3). In general, acquisition of the c-onc gene is accompanied by various alterations, including single base changes and deletions, and ...
C, Van Beveren   +4 more
openaire   +2 more sources

Proto-oncogene fos: a multifaceted gene

Trends in Genetics, 1986
Abstract Both v- fos and c- fos proteins, despite their altered carboxyl terminus, are nuclear and can transform fibroblasts in vitro . The c- fos protein exhibits complex regulation involving interaction with 3′ non-coding sequences of c- fos RNA.
openaire   +1 more source

Epithelioid osteoblastoma with secondary aneurysmal bone cyst and FOS gene rearrangement

Skeletal Radiology, 2021
Epithelioid osteoblastoma, sometimes equated with aggressive osteoblastoma, is a variant of osteoblastoma that typically demonstrates more worrisome imaging and pathological features compared to conventional osteoblastoma. These more aggressive features can overlap with those seen in osteosarcoma, creating a diagnostic challenge for radiologists and ...
Justin T. Snow   +4 more
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The Role of FOS in Gene Regulation

1990
The cellular protooncogene FOS is expressed at very low level in most cells of the organism and in most growing cells in culture. The synthesis is rapidly elevated if cells are exposed to one of a large number of agents and conditions. This suggests that FOS is an intermediate in the signal transfer of a variety of different specific genetic responses.
Herrlich, P.   +7 more
openaire   +1 more source

Retinal degeneration, apoptosis and the c-fos gene

Neuro-Ophthalmology, 1998
In the past few years, the interest in the research field of apoptosis in the retina has been growing rapidly. We will give a short overview of apoptosis in the context of retinal degeneration and summarize recent data obtained in our laboratory. Based on our findings, we will also discuss possible future strategies to influence apoptotic cell death in
Farhad Hafezi   +3 more
openaire   +1 more source

Variations in c-fos gene expression during rat brain development

Molecular Brain Research, 1988
Expression of the c-fos proto-oncogene has been associated with mitosis or differentiation in a number of tissue culture model systems. We have studied the expression of this gene during in vivo brain development in the rat. Our results demonstrate that very low levels of c-fos mRNA are detectable during the period of development characterized by rapid
R M, Gubits, J L, Hazelton, R, Simantov
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The c-fos gene and early-onset familial Alzheimer's disease

Neuroscience Letters, 1993
A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome (YAC) clone was identified which contains FOS.
Lori L.C. Bonnycastle   +13 more
openaire   +2 more sources

Molecular mechanisms for somatostatin inhibition of c-fos gene expression

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1997
We reported previously that somatostatin inhibits the expression of the immediate early gene c-fos. Accordingly, we characterized the molecular mechanisms by which somatostatin inhibits c-fos gene expression. Because growth factors activate c-fos through a region of its promoter known as the serum response element [SRE; base pairs (bp) -357 to -276 ...
A, Todisco   +4 more
openaire   +2 more sources

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

Cell, 1983
The complete nucleotide sequence of the FBJ-MuSV proviral DNA and the cellular homolog (c-fos) of its oncogene (v-fos) have been determined. The 4026 nucleotide long FBJ-MuSV proviral DNA contains two long terminal repeats, a substitution of 1639 nucleotides of mouse cellular DNA (v-fos) and the 3' end of the env gene derived from FBJ-MuLV.
C, Van Beveren   +4 more
openaire   +2 more sources

Proto-oncogene fos: an inducible gene.

Princess Takamatsu symposia, 1988
Proto-oncogene fos is a multifaceted gene, which is expressed during cell growth, cell differentiation, and development. The viral homologue, v-fos, was identified as the resident transforming gene of FBJ-murine osteosarcoma virus which induces bone tumors in mice.
I M, Verma   +2 more
openaire   +1 more source

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