Sensitive and accurate DNA metabarcoding of parasitic helminth mock communities using the mitochondrial rRNA genes [PDF]
Scientific Reports, 2022 Next-generation sequencing technologies have accelerated the pace of helminth DNA metabarcoding research, enabling species detection in bulk community samples.
Chaisiri, Kittipong +7 more
core +6 more sources
Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]
PLoS Pathogens, 2015 Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
A Tarkowski +70 more
core +10 more sources
The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]
, 2013 Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara +48 more
core +18 more sources
Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome [PDF]
, 2017 Intestinal helminth infections occur pre dominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of ...
Borchers, Christoph H. +13 more
core +1 more source
Parasite excretory-secretory products and their effects on metabolic syndrome [PDF]
, 2017 Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is
Crowe, J. +3 more
core +2 more sources
microRNAs of parasitic helminths – identification, characterization and potential as drug targets [PDF]
, 2014 microRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. They were first identified in the free-living nematode Caenorhabditis elegans, where the miRNAs lin-4 and let-7 were shown to be essential for regulating ...
Britton, Collette +3 more
core +1 more source
Application of small RNA technology for improved control of parasitic helminths [PDF]
, 2015 Over the last decade microRNAs (miRNAs) and small interfering RNAs (siRNAs) have emerged as important regulators of post-transcriptional gene expression.
Britton, Collette +6 more
core +1 more source
A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]
, 2019 Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole +8 more
core +4 more sources
Mucosal immune responses following intestinal nematode infection. [PDF]
, 2014 In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Else KJ +11 more
core +2 more sources
The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma [PDF]
, 2020 BACKGROUND: Reference genome and transcriptome assemblies of helminths have reached a level of completion whereby secondary analyses that rely on accurate gene estimation or syntenic relationships can be now conducted with a high level of confidence ...
James, Katherine, Olson, Peter D.
core +2 more sources