Scientific Reports, 2022 Next-generation sequencing technologies have accelerated the pace of helminth DNA metabarcoding research, enabling species detection in bulk community samples.
Abigail Hui En Chan +7 more
doaj +4 more sources
Intestinal helminth Schyzocotyle acheilognathi Yamaguti, 1934 infection ameliorate lipid metabolism of grass carp (Ctenopharyngodon idella) through immune and gut microbiota regulation [PDF]
Frontiers in MicrobiologyFats have been widely applied in aquaculture to promote growth performance and substitute partial protein in fish feeds. However, excessive dietary fat levels induce metabolic disorders harming the health of cultured fish.
Xiaoao Yang +3 more
doaj +2 more sources
Investigating the development of diarrhoea through gene expression analysis in sheep genetically resistant to gastrointestinal helminth infection [PDF]
Scientific Reports, 2022 Gastrointestinal helminths infect livestock causing health problems including severe diarrhoea. To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared 4 sheep that were susceptible to development of ...
Shamshad Ul Hassan +7 more
doaj +3 more sources
Delineating markers of disease-disease interaction: a systematic methodology and its application to multiple diabetes-helminth cohorts [PDF]
BMC BioinformaticsBackground Understanding how the molecules in our bodyrespond to the co-occurrence of two diseases in an individual (comorbidity) could lead tomechanistic insights into novel treatments for comorbid conditions.
Nilesh Subramanian +5 more
doaj +2 more sources
Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on
Veterinary Research, 2011 Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and
Lühken Gesine +3 more
doaj +4 more sources
Genetics of helminth infections: Immune system response, insights into host-parasite interaction, and drug resistance [PDF]
Journal of Advanced Veterinary and Animal ResearchHelminthiases, which are caused by parasitic helminths, have a big effect on global health, especially in places with few resources. They cause a lot of illness and put a lot of strain on society and the economy.
Mashael Abdullah Aldamigh
doaj +2 more sources
Hookworm infection modulates lung and intestinal transcriptomic responses to SARS-CoV-2 in Syrian hamsters [PDF]
Frontiers in ImmunologyBackgroundHelminth infections are widespread in resource-limited settings, and modulate host immune responses, with potential implications for viral coinfections.
Bruce A. Rosa +11 more
doaj +2 more sources
Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state. [PDF]
Acta Crystallogr D Struct BiolStructural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Parker KL +7 more
europepmc +2 more sources
Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells [PDF]
Frontiers in ImmunologyBackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo +7 more
doaj +4 more sources
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. [PDF]
PLoS Neglected Tropical Diseases, 2016 Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also ...
Guangyan Zhou +3 more
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