Results 11 to 20 of about 24,986 (221)

Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells [PDF]

Frontiers in Immunology
BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo   +7 more
doaj   +4 more sources

The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]

, 2013
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara, A Roepstorff, A Zhao, A Zhao, Aaron R. Jex, BA Vallance, C Dold, C Moolenbeek, C Zhou, CD Criscione, CV Holland, D Leles, D Masure, Dries Masure, DW Crompton, F van Wijk, G Jungersen, GH Liu, HD Dawson, J Vandesompele, JF Urban Jr, Jimmy Saunders, Johnny Vlaminck, Jozef Vercruysse, KD Mccoy, Koen Chiers, L Eriksen, M Ashraf, M Morimoto, N Arizono, N Foster, N Miquel, NL Harris, P Kermanizadeh, P Nejsum, P O'Lorcain, PA Knight, Peter Geldhof, PI Uston, R Shamri, RM Anthony, RW Li, S Rozen, S Schmidt, Sarah Claerhoudt, Tao Wang, TB Stewart, TJ Anderson, Wim Van den Broeck   +48 more
core   +31 more sources

Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5-Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection. [PDF]

Parasite Immunol
ABSTRACT The IL‐33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL‐33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation; however, the role of IL‐33‐driven mast cell responses in helminth infection is poorly understood.
Ong NWP, Hodge SH, Baker CP, Smyth DJ, Frangova T, McSorley HJ.   +5 more
europepmc   +2 more sources

Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. [PDF]

PLoS Neglected Tropical Diseases, 2016
Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also ...
Guangyan Zhou, Mary M Stevenson, Timothy G Geary, Jianguo Xia   +3 more
doaj   +1 more source

Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression [PDF]

ASN Neuro, 2015
In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammatory) response causes central nervous system inflammation; however, the mechanisms by which helminth parasites ...
Arun Chauhan, Fredice Z. Quenum, Ata Abbas, David S. Bradley, Sergei Nechaev, Brij B. Singh, Jyotika Sharma, Bibhuti B. Mishra   +7 more
openaire   +4 more sources

Gene expression patterns during adaptation of a helminth parasite to different environmental niches [PDF]

Genome Biology, 2007
Abstract Background Schistosome bloodflukes are complex trematodes responsible for 200 million cases of schistosomiasis worldwide. Their life cycle is characterized by a series of remarkable morphological and biochemical transitions between an invertebrate host, an aquatic environment, and a mammalian ...
Emmitt R. Jolly, Chen-Shan Chin, Steve Miller, Mahmoud Mohamed Bahgat, K. C. Lim, Joseph L. DeRisi, James H. McKerrow   +6 more
openaire   +4 more sources

Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.

PLoS Pathogens, 2021
Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection.
B Karina Montero, Wasimuddin, Nina Schwensow, Mark A F Gillingham, Yedidya R Ratovonamana, S Jacques Rakotondranary, Victor Corman, Christian Drosten, Jörg U Ganzhorn, Simone Sommer   +9 more
doaj   +2 more sources

HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. [PDF]

PLoS ONE, 2011
A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as ...
Sahar Abubucker, John Martin, Christina M Taylor, Makedonka Mitreva   +3 more
doaj   +1 more source

The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma [PDF]

, 2020
BACKGROUND: Reference genome and transcriptome assemblies of helminths have reached a level of completion whereby secondary analyses that rely on accurate gene estimation or syntenic relationships can be now conducted with a high level of confidence ...
James, Katherine, Olson, Peter D.
core   +2 more sources

Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study

Parasites & Vectors, 2020
Background Approximately 30% of children worldwide are infected with gastrointestinal parasites. Depending on the species, parasites can disrupt intestinal bacterial microbiota affecting essential vitamin biosynthesis.
Rojelio Mejia, Ashish Damania, Rebecca Jeun, Patricia E. Bryan, Paola Vargas, Marisa Juarez, Pamela S. Cajal, Julio Nasser, Alejandro Krolewiecki, Emilie Lefoulon, Courtney Long, Evan Drake, Rubén O. Cimino, Barton Slatko   +13 more
doaj   +1 more source