Investigating the development of diarrhoea through gene expression analysis in sheep genetically resistant to gastrointestinal helminth infection [PDF]
Scientific Reports, 2022 Gastrointestinal helminths infect livestock causing health problems including severe diarrhoea. To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared 4 sheep that were susceptible to development of ...
Shamshad Ul Hassan +7 more
doaj +3 more sources
Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on
Veterinary Research, 2011 Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and
Lühken Gesine +3 more
doaj +5 more sources
Exploring Genetic Factors Associated with <i>Moniezia</i> spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach. [PDF]
Animals (Basel)Gastrointestinal parasite (GIP) infections pose significant challenges in pasture-based sheep farming, leading to economic losses and welfare concerns. This study aimed to uncover the genetic basis of resistance to Moniezia spp.
Arzik Y +5 more
europepmc +2 more sources
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. [PDF]
PLoS Neglected Tropical Diseases, 2016 Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also ...
Guangyan Zhou +3 more
doaj +1 more source
Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana. [PDF]
PLoS Neglected Tropical Diseases, 2008 Helminth infections are prevalent in rural areas of developing countries and have in some studies been negatively associated with allergic disorders and atopy. In this context little is known of the molecular mechanisms of modulation involved.
Franca C Hartgers +11 more
doaj +1 more source
Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages. [PDF]
PLoS Pathogens, 2013 Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against ...
Julia Esser-von Bieren +9 more
doaj +1 more source
Searching for antigen B genes and their adaptive sites in distinct strains and species of the helminth Echinococcus [PDF]
Infection, Genetics and Evolution, 2006 Twenty-seven PCR-derived antigen B (AgB) nucleotide sequences from four Echinococcus species (Echinococcus granulosus, Echinococcus multilocularis, Echinococcus oligarthrus and Echinococcus vogeli) were aligned with 78 already published sequences, to generate a maximum likelihood phylogeny of the AgB multigene family. The phylogenetic analysis confirms
Karen Luisa Haag +6 more
openaire +5 more sources
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression [PDF]
ASN Neuro, 2015 In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammatory) response causes central nervous system inflammation; however, the mechanisms by which helminth parasites ...
Ata Abbas +7 more
openaire +5 more sources
PLoS Pathogens, 2021 Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection.
B Karina Montero +9 more
doaj +2 more sources
HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. [PDF]
PLoS ONE, 2011 A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as ...
Sahar Abubucker +3 more
doaj +1 more source