Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]
PLoS Pathogens, 2015 Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
Jessica C Jang +11 more
doaj +23 more sources
Comparative transcriptomics of stickleback immune gene responses upon infection by two helminth parasites, Diplostomum pseudospathaceum and Schistocephalus solidus [PDF]
Zoology, 2016 Immune systems of vertebrates are much more diverse than previously thought, in particular at the base of the vertebrate clade. RNA-seq was used to describe in detail the transcriptomic response of stickleback hosts to infection by two helminth parasites, the trematode Diplostomum pseudospathaceum (2 genotypes plus a genotype mix) and the cestode ...
Haase, David +8 more
openaire +5 more sources
The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]
, 2013 Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara +48 more
core +31 more sources
Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana. [PDF]
PLoS Neglected Tropical Diseases, 2008 Helminth infections are prevalent in rural areas of developing countries and have in some studies been negatively associated with allergic disorders and atopy. In this context little is known of the molecular mechanisms of modulation involved.
Franca C Hartgers +11 more
doaj +1 more source
Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages. [PDF]
PLoS Pathogens, 2013 Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against ...
Julia Esser-von Bieren +9 more
doaj +1 more source
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression [PDF]
ASN Neuro, 2015 In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammatory) response causes central nervous system inflammation; however, the mechanisms by which helminth parasites ...
Arun Chauhan +7 more
openaire +4 more sources
PLoS Pathogens, 2021 Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection.
B Karina Montero +9 more
doaj +2 more sources
Gene expression patterns during adaptation of a helminth parasite to different environmental niches [PDF]
Genome Biology, 2007 Abstract Background Schistosome bloodflukes are complex trematodes responsible for 200 million cases of schistosomiasis worldwide. Their life cycle is characterized by a series of remarkable morphological and biochemical transitions between an invertebrate host, an aquatic environment, and a mammalian ...
Emmitt R. Jolly +6 more
openaire +4 more sources
HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. [PDF]
PLoS ONE, 2011 A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as ...
Sahar Abubucker +3 more
doaj +1 more source
Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study
Parasites & Vectors, 2020 Background Approximately 30% of children worldwide are infected with gastrointestinal parasites. Depending on the species, parasites can disrupt intestinal bacterial microbiota affecting essential vitamin biosynthesis.
Rojelio Mejia +13 more
doaj +1 more source