Frontiers in Cellular and Infection Microbiology, 2021 As an adaption to their complex lifecycles, helminth parasites garner a unique repertoire of genes at different developmental stages with subtle regulatory mechanisms.
Yi Mu +3 more
doaj +1 more source
Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1. [PDF]
PLoS ONE, 2016 Helminth infections and allergic diseases are associated with IgE hyperresponsiveness but the genetics of this phenotype remain to be defined. Susceptibility to Ascaris lumbricoides infection and antibody levels to this helminth are associated with ...
Nathalie Acevedo +8 more
doaj +1 more source
B cell fate mapping reveals their contribution to the memory immune response against helminths
Frontiers in Immunology, 2022 An estimated quarter of the human world population is infected with gastrointestinal helminths causing major socioeconomic problems in endemic countries.
Paul Haase +5 more
doaj +1 more source
Diagnostics, 2023 Background: Intestinal helminth parasites are potent stimulators of T helper type 2 (Th2) and regulatory Th3 anti-inflammatory immune responses, while human immunodeficiency virus (HIV) infections are activators of predominantly T helper type 1(Th1) pro-inflammatory responses.
Miranda N. Mpaka-Mbatha +6 more
openaire +3 more sources
The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma [PDF]
, 2020 BACKGROUND: Reference genome and transcriptome assemblies of helminths have reached a level of completion whereby secondary analyses that rely on accurate gene estimation or syntenic relationships can be now conducted with a high level of confidence ...
James, Katherine, Olson, Peter D.
core +2 more sources
A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]
, 2019 Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole +8 more
core +4 more sources
The landscape of human genes involved in the immune response to parasitic worms
BMC Evolutionary Biology, 2010 Background More than 2 billion individuals worldwide suffer from helminth infections. The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight.
Fumagalli Matteo +6 more
doaj +1 more source
Plasticity of migrating CD1b+ and CD1b- lymph dendritic cells in the promotion of Th1, Th2 and Th17 in response to Salmonella and helminth secretions. [PDF]
PLoS ONE, 2013 Dendritic cells (DCs) are pivotal in the development of specific T-cell responses to control pathogens, as they govern both the initiation and the polarization of adaptive immunity.
Michel Olivier +4 more
doaj +1 more source
Mucosal immune responses following intestinal nematode infection. [PDF]
, 2014 In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Else KJ +11 more
core +4 more sources
Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host
Parasites & Vectors, 2021 Background Ascaris lumbricoides is the most common causative agent of soil-transmitted helminth infections worldwide, with an estimated 450 million people infected with this nematode globally.
Norashikin Mohd-Shaharuddin +3 more
doaj +1 more source