Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study
Parasites & Vectors, 2020 Background Approximately 30% of children worldwide are infected with gastrointestinal parasites. Depending on the species, parasites can disrupt intestinal bacterial microbiota affecting essential vitamin biosynthesis.
Rojelio Mejia +13 more
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Frontiers in Cellular and Infection Microbiology, 2021 As an adaption to their complex lifecycles, helminth parasites garner a unique repertoire of genes at different developmental stages with subtle regulatory mechanisms.
Yi Mu +3 more
doaj +1 more source
Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1. [PDF]
PLoS ONE, 2016 Helminth infections and allergic diseases are associated with IgE hyperresponsiveness but the genetics of this phenotype remain to be defined. Susceptibility to Ascaris lumbricoides infection and antibody levels to this helminth are associated with ...
Nathalie Acevedo +8 more
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B cell fate mapping reveals their contribution to the memory immune response against helminths
Frontiers in Immunology, 2022 An estimated quarter of the human world population is infected with gastrointestinal helminths causing major socioeconomic problems in endemic countries.
Paul Haase +5 more
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Plasticity of migrating CD1b+ and CD1b- lymph dendritic cells in the promotion of Th1, Th2 and Th17 in response to Salmonella and helminth secretions. [PDF]
PLoS ONE, 2013 Dendritic cells (DCs) are pivotal in the development of specific T-cell responses to control pathogens, as they govern both the initiation and the polarization of adaptive immunity.
Michel Olivier +4 more
doaj +1 more source
The landscape of human genes involved in the immune response to parasitic worms
BMC Evolutionary Biology, 2010 Background More than 2 billion individuals worldwide suffer from helminth infections. The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight.
Fumagalli Matteo +6 more
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Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host
Parasites & Vectors, 2021 Background Ascaris lumbricoides is the most common causative agent of soil-transmitted helminth infections worldwide, with an estimated 450 million people infected with this nematode globally.
Norashikin Mohd-Shaharuddin +3 more
doaj +1 more source
Diagnostics, 2023 Background: Intestinal helminth parasites are potent stimulators of T helper type 2 (Th2) and regulatory Th3 anti-inflammatory immune responses, while human immunodeficiency virus (HIV) infections are activators of predominantly T helper type 1(Th1) pro-inflammatory responses.
Miranda N. Mpaka-Mbatha +6 more
openaire +3 more sources
Haemonchus contortus P-glycoproteins interact with host eosinophil granules: a novel insight into the role of ABC transporters in host-parasite interaction. [PDF]
PLoS ONE, 2014 Eosinophils are one of the major mammalian effector cells encountered by helminths during infection. In the present study, we investigated the effects of eosinophil granule exposure on the sheep parasitic nematode Haemonchus contortus as a model.
Mohamed Issouf +8 more
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Effect of heterogeneous mixing and vaccination on the dynamics of anthelmintic resistance: a nested model. [PDF]
PLoS ONE, 2010 Anthelmintic resistance is a major threat to current measures for helminth control in humans and animals. The introduction of anthelmintic vaccines, as a complement to or replacement for drug treatments, has been advocated as a preventive measure.
Lorenzo Sabatelli
doaj +1 more source