Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and <i>Atp4a</i> <sup>-/-</sup> mice. [PDF]
Liu K, Zhang X, Li FZ, Zheng PY, Mi Y.
europepmc +1 more source
ABSTRACT Background Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT), is an exceptionally rare and highly aggressive ovarian malignancy affecting predominantly young women. Its overlapping morphology with other poorly differentiated ovarian tumours and lack of specific early markers frequently lead to diagnostic delay.
Mahendra Kumar +8 more
wiley +1 more source
Transcriptomic characterization of mucosal hemocytes in the eastern oyster (<i>Crassostrea virginica</i>) underlines their potential role as immune sentinels. [PDF]
Abdallah S +3 more
europepmc +1 more source
TRIAGE Toolkit: Streamlined Discovery of Regulatory Genes and Elements
Abstract Efficient discovery of regulatory genes and elements is essential for understanding cell identity, differentiation, and disease mechanisms. The TRIAGE methods are a set of well‐established computational approaches that identify context‐specific regulatory genes and prioritize regulatory elements across the genome.
Qiongyi Zhao +6 more
wiley +1 more source
Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study. [PDF]
Ruf S +18 more
europepmc +1 more source
This article systematically reviews how insulin resistance (IR) disrupts endometrial receptivity by interfering with glucose metabolism mechanisms, ultimately leading to infertility in patients with Polycystic Ovary Syndrome (PCOS). ABSTRACT Introduction Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS)
Si‐yan Huang +7 more
wiley +1 more source
Genetic analysis of Han-Chinese patients with isolated congenital ptosis. [PDF]
Zhang QL +6 more
europepmc +1 more source
Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
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Homeobox B13 activates the hypoxia-inducible factor 1 pathway through histone lactylation thereby reprogramming lipid metabolism and promoting sorafenib resistance in hepatocellular carcinoma. [PDF]
Xie Q +5 more
europepmc +1 more source
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu +11 more
wiley +1 more source

