Results 211 to 220 of about 119,722 (304)

Homeobox B13 activates the hypoxia‐inducible factor 1 pathway through histone lactylation thereby reprogramming lipid metabolism and promoting sorafenib resistance in hepatocellular carcinoma

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Lactylation‐mediated metabolism reprogramming in HCC sorafenib resistance. In sorafenib‐resistant hepatocellular carcinoma (HCC) cells, lactate accumulation drives histone H3 lysine 18 lactylation (H3K18la). This modification is specifically enriched in the promoter region of homeobox B13 (HOXB13), activating HOXB13 transcription and upregulating its ...
Qingqing Xie   +5 more
wiley   +1 more source

Transcriptomic Analysis of Adult Mouse Cardiac Stromal Cells Using Single-Cell qRT-PCR. [PDF]

open access: yesCells
Alonaizan R   +5 more
europepmc   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

open access: yesClinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high‐throughput RNA sequencing

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro   +5 more
wiley   +1 more source

Genetic control of wheat flour end‐use quality and rheology by genome‐wide association studies

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Improving end‐use quality in bread wheat (Triticum aestivum) requires dissecting the genetic basis of complex processing traits and deploying robust prediction pipelines in breeding. We performed genome‐wide association studies (GWASs) using 1767 high‐quality single‐nucleotide polymorphisms generated by genotyping‐by‐sequencing in a diverse ...
Juan Menor de Gaspar   +10 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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