Lactylation‐mediated metabolism reprogramming in HCC sorafenib resistance. In sorafenib‐resistant hepatocellular carcinoma (HCC) cells, lactate accumulation drives histone H3 lysine 18 lactylation (H3K18la). This modification is specifically enriched in the promoter region of homeobox B13 (HOXB13), activating HOXB13 transcription and upregulating its ...
Qingqing Xie +5 more
wiley +1 more source
Transcriptomic Analysis of Adult Mouse Cardiac Stromal Cells Using Single-Cell qRT-PCR. [PDF]
Alonaizan R +5 more
europepmc +1 more source
The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley +1 more source
Genetic and genomic analyses of tree architectural traits in Hevea brasiliensis revealed genes underlying QTLs linked to key developmental processes. [PDF]
Prasetyo NE +4 more
europepmc +1 more source
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro +5 more
wiley +1 more source
The Chronological Trigger: The Orchestra Between Homeobox Genes and the Circadian Clock During Development. [PDF]
Poloni JF, Feltes BC.
europepmc +1 more source
Genetic control of wheat flour end‐use quality and rheology by genome‐wide association studies
Abstract Improving end‐use quality in bread wheat (Triticum aestivum) requires dissecting the genetic basis of complex processing traits and deploying robust prediction pipelines in breeding. We performed genome‐wide association studies (GWASs) using 1767 high‐quality single‐nucleotide polymorphisms generated by genotyping‐by‐sequencing in a diverse ...
Juan Menor de Gaspar +10 more
wiley +1 more source
Dissection of genomic regions underlying early seedling vigour in chickpea through genome-wide association mapping. [PDF]
Dasgupta U +5 more
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source

