Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study [PDF]
Frontiers in ImmunologyBackgroundAsthma exhibits heterogeneity, including type 2 (T2-high) and non-T2 phenotypes. This study aimed to elucidate the inflammatory mechanisms that drive non-type 2 asthma, a subtype characterized by low immunoglobulin E levels and negative ...
Jyh-Hong Lee +7 more
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Immunoglobulin germline reference sequences enable investigations and reveal insights into bat-specific immunity [PDF]
iScienceSummary: We generated a highly contiguous, annotated genome of the Jamaican fruit bat, Artibeus jamaicensis, including annotated germline immunoglobulin heavy-chain (IGH) and light-chain lambda (IGL) loci to understand bat B cell receptor repertoires ...
Ashley B. Reers +7 more
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AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]
Annals of Mechnikov's Institute, 2019 Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes.In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).The activity of AID is ...
T Kolotova +3 more
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Genomic features of humoral immunity support tolerance model in Egyptian rousette bats
Cell Reports, 2021 Summary: Bats asymptomatically harbor many viruses that can cause severe human diseases. The Egyptian rousette bat (ERB) is the only known reservoir for Marburgviruses and Sosuga virus, making it an exceptional animal model to study antiviral mechanisms ...
Peter A. Larson +8 more
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Frontiers in Immunology, 2021 Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin
Yixun Huang +2 more
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Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch. [PDF]
PLoS ONE, 2017 Previous studies on a limited number of birds suggested that the IgD-encoding gene was absent in birds. However, one of our recent studies showed that the gene was definitely expressed in the ostrich and emu.
Binyue Han +5 more
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A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana). [PDF]
PLoS ONE, 2011 The genomic organization of the IgH (Immunoglobulin heavy chain), Igκ (Immunoglobulin kappa chain), and Igλ (Immunoglobulin lambda chain) loci in the African elephant (Loxodonta africana) was annotated using available genome data.
Yongchen Guo +6 more
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AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]
PLoS ONE, 2012 Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich +2 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Educational Items on Immunoglobulin genes.
Lefranc, MP, Huret, JL
openaire +3 more sources
BMJ Open Diabetes Research & Care, 2023 Introduction To identify proteins and corresponding genes that share sequential and structural similarity with programmed cell death protein-1 (PD-1) in patients with type 1 diabetes mellitus (T1DM) via bioinformatics analysis.Research design and methods
Wu Zhang +6 more
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