Results 21 to 30 of about 5,788,302 (308)

Presence of PD-1 similarity genes in monocytes may promote the development of type 1 diabetes mellitus and poor prognosis of pancreatic cancer

BMJ Open Diabetes Research & Care, 2023
Introduction To identify proteins and corresponding genes that share sequential and structural similarity with programmed cell death protein-1 (PD-1) in patients with type 1 diabetes mellitus (T1DM) via bioinformatics analysis.Research design and methods
Wu Zhang, Wenchuan Zhang, Wanfeng Xu, Can Xu, Mingming Zhang, Yuquan Huang, Qingxia Li   +6 more
doaj   +1 more source

Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Клиническая онкогематология, 2019
Background. Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers.
Yana Konstantinovna Mangasarova, Yu. V. Sidorova, A. U. Magomedova, B. V. Biderman, E. E. Nikulina, A. B. Sudarikov, A. M. Kovrigina, S. K. Kravchenko   +7 more
doaj   +1 more source

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (Camelus bactrianus) [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids.
Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN
doaj   +1 more source

Data on haplotype-supported immunoglobulin germline gene inference

Data in Brief, 2017
Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described.
Ufuk Kirik, Lennart Greiff, Fredrik Levander, Mats Ohlin   +3 more
doaj   +1 more source

The Determinants of B Cell Receptor Signaling as Prototype Molecular Biomarkers of Leukemia

Frontiers in Oncology, 2021
Advanced genome-wide association studies (GWAS) identified several transforming mutations in susceptible loci which are recognized as valuable prognostic markers in chronic lymphocytic leukemia (CLL) and B cell lymphoma (BCL).
Antonella Nicolò, Alexandra Theresa Linder, Hassan Jumaa, Palash Chandra Maity   +3 more
doaj   +1 more source

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

Journal of Experimental Medicine, 1998
Immunoglobulin (Ig)M+IgD+ B cells are generally assumed to represent antigen-inexperienced, naive B cells expressing variable (V) region genes without somatic mutations. We report here that human IgM+IgD+ peripheral blood (PB) B cells expressing the CD27
U. Klein, K. Rajewsky, R. Küppers
semanticscholar   +1 more source

Immunoglobulin G glycosylation in aging and diseases.

Cellular Immunology, 2018
The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations. IgG glycome composition is influenced both by genes and by environment, making it an excellent biomarker of a person's ...
I. Gudelj, G. Lauc, Marija Pezer
semanticscholar   +1 more source

Immunoglobulin and T Cell Receptor Genes: IMGT® and the Birth and Rise of Immunoinformatics

Frontiers in Immunology, 2014
IMGT®, the international ImMunoGeneTics information system®1, (CNRS and Université Montpellier 2) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the
M. Lefranc
semanticscholar   +1 more source

Pronounced cohabitation of active immunoglobulin genes from three different chromosomes in transcription factories during maximal antibody synthesis

Genes & Development, 2014
Here, Park et al. used 3D imaging and ChIP-3C techniques to investigate the topographies of the immunoglobulin (Ig) genes and transcripts during B-cell development.
Sung-Kyun Park, Yougui Xiang, Xin Feng, W. Garrard   +3 more
semanticscholar   +1 more source

Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis. [PDF]

PLoS ONE, 2012
In this study we were interested in identification of new markers of chicken response to Salmonella Enteritidis infection. To reach this aim, gene expression in the spleens of naive chickens and those intravenously infected with S.
Marta Matulova, Jana Rajova, Lenka Vlasatikova, Jiri Volf, Hana Stepanova, Hana Havlickova, Frantisek Sisak, Ivan Rychlik   +7 more
doaj   +1 more source