Results 41 to 50 of about 224,267 (330)

Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems [PDF]

, 2016
CD1 genes encode cell surface molecules that present lipid antigens to various kinds of T lymphocytes of the immune system. The structures of CD1 genes and molecules are like the major histocompatibility complex (MHC) class I system, the loading of ...
Kaufman, Jim, Rogers, Sally L
core   +2 more sources

Block-based Bayesian epistasis association mapping with application to WTCCC type 1 diabetes data [PDF]

, 2014
Interactions among multiple genes across the genome may contribute to the risks of many complex human diseases. Whole-genome single nucleotide polymorphisms (SNPs) data collected for many thousands of SNP markers from thousands of individuals under the ...
Liu, Jun, Zhang, Jing, Zhang, Yu
core   +1 more source

Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]

, 2012
The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia, Barson, C. van Oosterhout, Castric, Cvitanich, Eimes, Ellegren, Fraser, Fraser, Fraser, Gibbs, Hughes, Hughes, Hughes, Hughes, Jensen, Kanagawa, Li, M. McMullan, Martin, Mehta, Mona, Nei, Piertney, Posada, Smith, Spurgin, Stone, Uyenoyama, Uyenoyama, V. Llaurens, van Oosterhout, Willing   +32 more
core   +1 more source

Organization of Mhc class II B genes in the zebrafish (Brachydanio rerio).

Genomics, 1994
Using three genomic phage libraries, we isolated 26 clones from the zebrafish MHC class II B region. By restriction mapping, the clones could be arranged into six clusters, most clusters consisting of several overlapping clones.
H. Sültmann, W. Mayer, F. Figueroa, C. O’hUigin, J. Klein   +4 more
semanticscholar   +1 more source

Chromosome-level genome assembly of Patagonian moray cod (Muraenolepis orangiensis) and immune deficiency of major histocompatibility complex (MHC) class II

Frontiers in Marine Science, 2023
The Patagonian moray cod, Muraenolepis orangiensis, belongs to the family Muraenolepididae and is the sole order of Gadiformes that inhabits the temperate and cold waters of the southern hemisphere.
Jinmu Kim, Seung Jae Lee, Euna Jo, Euna Jo, Eunkyung Choi, Minjoo Cho, Soyun Choi, Jeong-Hoon Kim, Hyun Park   +8 more
doaj   +1 more source

The MHC and the Recognition of Self and Altered Self in Experimental and Rheumatoid Arthritis [PDF]

, 2014
The Major histocompatibility complex (MHC) is a highly polymorphic and genedense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity.
Haag, Sabrina
core   +1 more source

Compartmentalization of MHC class II gene expression in transgenic mice [PDF]

Cell, 1988
A set of transgenic mouse lines carrying Ek alpha genes with promoter region deletions was created in an attempt to compartmentalize MHC class II gene expression. Fine immunohistological analyses established that one transgenic line is essentially devoid of E complex in the thymic cortex, another displays almost no E in the thymic medulla or on ...
W, van Ewijk, Y, Ron, J, Monaco, J, Kappler, P, Marrack, M, Le Meur, P, Gerlinger, B, Durand, C, Benoist, D, Mathis   +9 more
openaire   +2 more sources

Gene duplication and fragmentation in the zebra finch major histocompatibility complex

BMC Biology, 2010
Background Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken
Burt David W, Kotkiewicz Holly, Godinez Ricardo, Westerdahl Helena, Völker Martin, Ekblom Robert, Balakrishnan Christopher N, Graves Tina, Griffin Darren K, Warren Wesley C, Edwards Scott V   +10 more
doaj   +1 more source

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

PLoS Biology, 2021
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman   +9 more
doaj   +1 more source

Linkage of LMP, TAP, and RING3 with Mhc class I rather than class II genes in the zebrafish.

Journal of Immunology, 1997
The LMP2 and LMP7 genes code for subunits of the proteasome, a multimeric enzymatic complex that degrades proteins into peptides. The two subunits replace corresponding constitutively expressed subunits during the immune response.
Kimitaka Takami, Z. Zaleska-Rutczynska, F. Figueroa, Jan Klein   +3 more
semanticscholar   +1 more source