Results 41 to 50 of about 520,866 (339)

Evolutionary genetics of MHC class II beta genes in the brown hare, Lepus europaeus [PDF]

, 2011
The genes of the major histocompatibility complex (MHC) are attractive candidates for investigating the link between adaptive variation and individual fitness.
A Aguilar, A Averdam, A Averdam, A Begovich, C Loiseau, C Stamatis, D Garrigan, D Gomez, D Čížková, DJ Wilson, EW Petersdorf, F Göritz, F Rousset, Franz Suchentrunk, G Bondinas, G McVean, G Wibbelt, GB Hartl, H Schaschl, H Schaschl, Helmut Schaschl, J Bryja, J Goüy de Bellocq, J Klein, J Schad, J Trowsdale, JA Anmarkrud, JG Bodmer, JH Brown, JL Campos, Joëlle Goüy de Bellocq, K Acevedo-Whitehouse, K Tamura, L Bernatchez, L Chouchane, L Excoffier, L Jost, LJ Stern, M Alcaide, M Amills, MK Oliver, ML Evans, P Awadalla, P Fearnhead, P Kasapidis, RJ Ladle, RR Hudson, S Smith, SB Piertney, Steve Smith, TA Hall   +50 more
core   +3 more sources

Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.

PLoS ONE, 2014
The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri, Janine Deakin, Ricardo M Godinez, Xueyan Shan, Daniel G Peterson, Sylvain Marthey, Eric Lyons, Fiona M McCarthy, Sally R Isberg, Damien P Higgins, Amanda Y Chong, John St John, Travis C Glenn, David A Ray, Jaime Gongora   +14 more
doaj   +1 more source

The Marine Mammal Class II Major Histocompatibility Complex Organization

Frontiers in Immunology, 2019
Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system ...
André Luiz Alves de Sá, André Luiz Alves de Sá, Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz Schneider   +7 more
doaj   +1 more source

Immunogenetic variation and differential pathogen exposure in free-ranging cheetahs across Namibian farmlands. [PDF]

PLoS ONE, 2012
Genes under selection provide ecologically important information useful for conservation issues. Major histocompatibility complex (MHC) class I and II genes are essential for the immune defence against pathogens from intracellular (e.g.
Aines Castro-Prieto, Bettina Wachter, Joerg Melzheimer, Susanne Thalwitzer, Heribert Hofer, Simone Sommer   +5 more
doaj   +1 more source

Positional identification and functional analysis of genes regulating autoimmune arthritis [PDF]

, 2016
The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA).
Yau, Anthony Chun Yeung
core   +1 more source

MHC Class II Deficiency

Medicine, 2001
IntroductionPrimary human immunodeficiencies constitute a heterogenous group of inborn errors of the immune system due to a variety of genetic abnormalities. The study of patients with primary immunodeficiency diseases has expanded our understanding of immunity.
B. Lisowska-Grospierre, Krzysztof Masternak, Jean Villard, Walter Reith, Alain Fischer   +4 more
openaire   +2 more sources

Major histocompatibility complex (MHC) fragment numbers alone – in Atlantic cod and in general - do not represent functional variability [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
This correspondence concerns a publication by Malmstrøm et al. in Nature Genetics in October 2016. Malmstrøm et al. made an important contribution to fish phylogeny research by using low-coverage genome sequencing for comparison of 66 teleost (modern ...
Johannes M. Dijkstra, Unni Grimholt
doaj   +1 more source

Structure and polymorphism of the major histocompatibility complex class II region in the Japanese Crested Ibis, Nipponia nippon. [PDF]

PLoS ONE, 2014
The major histocompatibility complex (MHC) is a highly polymorphic genomic region that plays a central role in the immune system. Despite its functional consistency, the genomic structure of the MHC differs substantially among organisms.
Yukio Taniguchi, Keisuke Matsumoto, Hirokazu Matsuda, Takahisa Yamada, Toshie Sugiyama, Kosuke Homma, Yoshinori Kaneko, Satoshi Yamagishi, Hiroaki Iwaisaki   +8 more
doaj   +1 more source

Compartmentalization of MHC class II gene expression in transgenic mice [PDF]

Cell, 1988
A set of transgenic mouse lines carrying Ek alpha genes with promoter region deletions was created in an attempt to compartmentalize MHC class II gene expression. Fine immunohistological analyses established that one transgenic line is essentially devoid of E complex in the thymic cortex, another displays almost no E in the thymic medulla or on ...
van Ewijk, Willem, Ron, Yacov, Monaco, John, Kappler, John, Marrack, Philippa, Le Meur, Marianne, Gerlinger, Pierre, DURAND, Beatrice,, Benoist, Christophe, Mathis, Diane   +9 more
openaire   +4 more sources

Major histocompatibility complex (MHC) fragment numbers alone – in Atlantic cod and in general - do not represent functional variability [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
This correspondence concerns a publication by Malmstrøm et al. in Nature Genetics in October 2016. Malmstrøm et al. made an important contribution to fish phylogeny research by using low-coverage genome sequencing for comparison of 66 teleost (modern ...
Johannes M. Dijkstra, Unni Grimholt
doaj   +1 more source