MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes [PDF]
Experimental and Molecular Pathology, 2008 Antigen presentation by Major Histocompatibility Complex (MHC) class II molecules plays an important role in controlling immunity and autoimmunity. Multiple co-factors including the invariant chain (Ii), HLA-DM and HLA-DO are involved in this process. While the role for Ii and DM has been well defined, the biological function of DO remains obscure. Our
Peter E. Jensen, Xinjian Chen
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Identification and characterization of a chicken major histocompatibility complex class II[beta] gene promoter [PDF]
, 1995 The major histocompatibility complex (MHC) contains a variety of genes. Among them, the class II genes encode proteins involved in antigen presentation to helper T cells, a key step in initiating immune responses.
Chen, Yunfei
core +3 more sources
Frontiers in Marine Science, 2023 The Patagonian moray cod, Muraenolepis orangiensis, belongs to the family Muraenolepididae and is the sole order of Gadiformes that inhabits the temperate and cold waters of the southern hemisphere.
Jinmu Kim +8 more
doaj +1 more source
PCR-based isolation of multigene families: Lessons from the avian MHC class IIB [PDF]
, 2013 The amount of sequence data available today highly facilitates the access to genes from many gene families. Universal primers amplifying the desired genes over a range of species are readily obtained by aligning conserved gene regions, and laborious gene isolation procedures can often be replaced by quicker PCR-based approaches.
arxiv +1 more source
Analyzing Lack of Concordance Between the Proteome and Transcriptome in Paired scRNA-Seq and Multiplexed Spatial Proteomics [PDF]
arXiv, 2023 In this study, we analyze discordance between the transcriptome and proteome using paired scRNA-Seq and multiplexed spatial proteomics data from HuBMAP. Our findings highlight persistent transcripts in key immune markers, including CD45-RO, Ki67, CD45, CD20, and HLA-DR.
arxiv
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes [PDF]
Journal of Experimental Medicine, 2016 Evidence has recently emerged that butyrophilins, which are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the immune system. We found that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to ...
Carla Lippens +22 more
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Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids
Frontiers in Genetics, 2022 This review summarizes the current knowledge on the major histocompatibility complex (MHC) of the family Felidae. This family comprises an important domestic species, the cat, as well as a variety of free-living felids, including several endangered ...
Martin Plasil +7 more
doaj +1 more source
Journal of Immunology, 1991 Ligands that bind MHC class II (Ia) molecules, including staphylococcal exotoxins (SE) and mAb induce IL-1 and TNF secretion in human monocytes and monocytic cell lines.
N. Trede, R. Geha, T. Chatila
semanticscholar +1 more source
Organization of Mhc class II B genes in the zebrafish (Brachydanio rerio).
Genomics, 1994 Using three genomic phage libraries, we isolated 26 clones from the zebrafish MHC class II B region. By restriction mapping, the clones could be arranged into six clusters, most clusters consisting of several overlapping clones.
H. Sültmann +4 more
semanticscholar +1 more source
Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish) [PDF]
, 1998 Acquired immunity in vertebrates is a major mechanism of the immune system, which enables the vertebrates to discriminate self and non-self The most important feature of acquired immunity is the major histocompatibility complex (MHC) restricted ...
Yang, Bingmei
core +2 more sources