Results 181 to 190 of about 2,142,199 (296)

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

lncRNA Lockd promotes cardiomyocyte proliferation via Eno1/beta-catenin/Myc axis. [PDF]

Mol Ther Nucleic Acids
Prakash S, Kundu S, Chaudhary AD, Chaudhary S, Kumar C, Kumari S, Singh S, Yadav B, Kumar A, Prajapati VM, Jagavelu K, Kumar S, Gupta SK.   +12 more
europepmc   +1 more source

Toward Objective Anal Cancer Screening: From Swab‐Based Genome‐Wide Methylation Marker Discovery to Novel Test Development

International Journal of Cancer, Volume 160, Issue 1, Page 187-200, 1 January 2027.
ABSTRACT Anal high‐grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab‐based screening and highlight the need for objective biomarkers to improve risk stratification.
Kirsten Rozemeijer, Jürgen Claesen, Fernando Dias Gonçalves Lima, Albertus T. Hesselink, Phoebe Klingers, Timo ter Braak, Yara van den Burgt, Chris J. L. M. Meijer, Jan M. Prins, Henry J. C. de Vries, Mark A. van de Wiel, Renske D. M. Steenbergen   +11 more
wiley   +1 more source

Prmt6 Deficiency Drives Osteoblast Senescence Promoting Age-Related Osteoporosis via Epigenetic Remodelling of the H3R2me2a/Sting/Ifitm3 Pathway. [PDF]

J Cell Mol Med
Wang Y, Ge X, Chang S, Wang D, Xu K, Xu H, Liu X, Wang S.   +7 more
europepmc   +1 more source

Detection of SARS‐CoV‐2 in Semen Months After COVID‐19: Potential Evidence of Low‐Level Replicative Persistence

Andrology, Volume 15, Issue 1, January 2027.
ABSTRACT Background Viral persistence is considered one of the key mechanisms driving long COVID symptoms. The male genital tract (MGT), particularly the testis, is an immune‐privileged site that may serve as a viral reservoir for SARS‐CoV‐2.
Marcelo H. Furtado, Fernanda R. Souza, Lidia M. Andrade, Bárbara P. Mendes, Juan C. González, Thiago P. Furtado, Anisleidy Pérez Castillo, Samyra M. S. N. Lacerda, Renato S. Aguiar, Guilherme M. J. Costa   +9 more
wiley   +1 more source

Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study. [PDF]

EBioMedicine
Lue JC, Stallings-Mann M, Hoskin T, McCauley BM, Vierkant RA, Pacheco-Spann L, Fischer JL, Gehling DL, Seymour LR, Baker DJ, Degnim AC, Winham SJ, Sherman ME, Radisky DC.   +13 more
europepmc   +1 more source

The loss of p16 expression in pancreatic carcinoma compared with p16 gene abnormalities

Japan Journal of Molecular Tumor Marker Research, 2000
Ohtsubo, Koushiro, Watanabe, Hiroyuki, Motoo, Yoshiharu, Okai, Takashi, Sawabu, Norio, Yasuyuki Asada, and   +5 more
openaire   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2692-2707, December 2026.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Targeting the senescence‒autophagy axis via p16^INK4a inhibition alleviates pulmonary fibrosis. [PDF]

Signal Transduct Target Ther
Yoo YJ, Zhang M, Jin SH, Lee YR, Jin H, Doan TP, Kim S, Choi S, Park EJ, Na S, Lee Y, Sun J, Cho J, Cho NC, Park SY, Oh WK, Lee YS.   +16 more
europepmc   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source