Results 231 to 240 of about 2,142,199 (296)

Engineering the FK228 biosynthetic gene clusters for high-yield production. [PDF]

Front Microbiol
Wang M, Jia X, Zhang Y, Ma J, Zhang Y, Fu J, Li R.   +6 more
europepmc   +1 more source

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
USP25‐mediated K63‐linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide targeting the USP25–SIRT1 interaction for anti‐senescence therapeutic intervention.
YuJuan Zhou, Xinshu Wang, Jiyuan Zhang, Hanqiong Qiang, Xinru Zhao, Jingyi Luo, Yanjun Ji, Jiakai Yao, Linhui Zhai, Tingting Zhang, Ke Li, Yuping Chen, Jian Yuan, Lei Li, Yunhui Li   +14 more
wiley   +1 more source

A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell dysfunction in human lymph nodes. [PDF]

Cell Press Blue
Farzad N, Enninful A, Lu Y, Parisi F, Fung A, Kwon Y, Li Y, Labrosse M, Yang M, Strino F, Chen L, Yang J, Zhong M, Gao F, Tao B, Cunningham J, Bai Z, Li H, Wang F, Stankewich M, Kim D, Dong M, Bramer LM, Li K, Bhat MR, Loe E, Craft J, Pasa-Tolic L, Halene S, Shi L, Kluger Y, Xu ML, Fan R.   +32 more
europepmc   +1 more source

MKP‐2 Genetic Depletion Modulates Adipose Lipid Composition, Cellular Senescence, and Aging in Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Excess white adipose tissue (WAT) accumulation promotes aging by increasing the risk of insulin resistance and chronic diseases and reduced lifespan. MKP‐2 deficiency protects against premature senescence in cells and WAT and is associated with adipose lipid remodeling, improved metabolic health, and longer lifespan.
Morgan Welch, Nabin Ghimire, Shauri Smith, Cassandra Secunda, Alexis Fink, Alissar Sleiman, Laura Chambliss, Christopher Pinckard, Chloe Reyes, Priya Katta, Anna Ai, Benjamin R. Harrison, Ahmed Lawan   +12 more
wiley   +1 more source

Intestinal pooling of taurine conjugated bile acids is associated with tissue aging and senescent immune evasion. [PDF]

Front Immunol
Tan J, Xiong W, Feng Y, Li X, Jiang H, Zhang Z.   +5 more
europepmc   +1 more source

The Dietary Polyphenol Epigallocatechin Gallate Delays Biological Aging by Activating Peroxisome Biogenesis and Peroxisomal Fatty Acid β‐Oxidation

Aging Cell, Volume 25, Issue 11, November 2026.
Dietary EGCG intake was associated with slower biological aging, lower mortality risk, and longer residual life expectancy in humans. Mechanistic studies in C. elegans and AML12 hepatocytes support peroxisome biogenesis and peroxisomal fatty acid β‐oxidation as key contributors to EGCG‐related longevity and anti‐senescent effects.
Xiaoming Huang, Yanfang Yang, Feng Huang, Wenwen Lin, Qiaowei Li, Yin Yuan, Pengli Zhu   +6 more
wiley   +1 more source

Citrate metabolism and mitochondrial DNA signaling: cooperative regulation of the senescence-associated secretory phenotype. [PDF]

Signal Transduct Target Ther
Hong G, Yoon H, Lee HO, Chung JH, Kim J.
europepmc   +1 more source

Long‐Term Post‐Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of In Vivo Aging and Enables Dynamic Testing of Anti‐Aging Compounds

Aging Cell, Volume 25, Issue 11, November 2026.
Human fibroblasts undergo accelerated molecular aging in long‐term culture, recapitulating in‐vivo aging signatures and increasing age‐related heterogeneity. Direct neuronal conversion preserves biological age, enabling pseudo‐longitudinal studies and a scalable platform to evaluate anti‐aging interventions, including the differential effects of ...
Larissa Traxler, Lukas Karbacher, Oliver Borgogno, Taylor Ozbun, Kylie Champion, Anna Smaling, Lucia Zhou‐Yang, Joseph R. Herdy, Lena Böhnke, Barbara C. Böckle, Fred H. Gage, Hildegard I. D. Mack, Michaela Defrancesco, Jerome Mertens   +13 more
wiley   +1 more source

ST6GAL1 Is a Functional Regulator of UVA-Induced Photoaging in Human Dermal Fibroblasts. [PDF]

Cells
Zhong J, Liang L, Wu M, Liang Y, Li M, Lee CL, Shu P.   +6 more
europepmc   +1 more source

The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities

Aging Cell, Volume 25, Issue 11, November 2026.
Sleep disruption and circadian decline drive inflammaging and immune aging via the gut‐brain axis, NLRP3, and TLR4, forming a vicious cycle that accelerates cognitive decline and epigenetic aging. Targeting this sleep‐immune axis offers a viable strategy for promoting healthy longevity. ABSTRACT Aging is characterized by two interdependent hallmarks: a
Fu‐Ying Zhao, Jia‐Mei Wang, Shi‐Yang Lu, Liang Hao, Hai‐Yan Zhang, Hua‐Qin Wang   +5 more
wiley   +1 more source