Results 221 to 230 of about 2,142,199 (296)

GDF15 participates in epithelial cell senescence in radiation-induced lung injury through the ERK1/2-p16 signaling pathway. [PDF]

PLoS One
Liu J, Lv D, Wang H, Yang D, Xu Y, Yan Y.   +5 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Mitochondrial metabolism and epigenetic crosstalk drive SASP. [PDF]

Nature
Martini H, Birch J, Marques FDM, Victorelli S, Lagnado AB, Pirius N, Franco AC, Lee G, Han Y, Rowsey JL, Ismail WM, Mazzone A, Espe TM, Hitosugi T, Li Y, Washington AM, Havas A, Murad R, Lei X, Porritt RA, Maddocks ODK, Machado Espindola-Netto J, Saul D, Khosla S, Jurk D, Kostallari E, Gaspar-Maia A, Adams PD, Passos JF.   +28 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, Volume 40, Issue 11, Page 6535-6552, November 2026.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, Volume 40, Issue 11, Page 6709-6747, November 2026.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

South African Speech‐Language Therapists’ Perceptions of Youth Offenders and Youth Offender Rehabilitation

International Journal of Language &Communication Disorders, Volume 61, Issue 6, November/December 2026.
ABSTRACT Background Healthcare professionals (HCPs) tend to display similar levels of implicit bias towards certain groups as the general population. This is concerning as such biases are known to result in poorer clinical decision‐making and therapeutic outcomes for offender populations.
Johan Jacobus Maasz, Christiaan Bezuidenhout, Marien Alet Graham, Jeannie van der Linde   +3 more
wiley   +1 more source

Senescence‐Associated Loss of α‐Synuclein in Brain Microvascular Endothelium Compromises Tight Junctions and Disrupts Blood–Brain Barrier Integrity

Aging Cell, Volume 25, Issue 11, November 2026.
Decline of SNCA in brain microvascular endothelium during vascular aging induces a senescence‐like stress state with p16/p53 activation, impaired SIRT1‐eNOS signaling, and reduced repair capacity. This is accompanied by BACE1 upregulation, tight‐junction disruption, BBB leakage, and Aβ42 vulnerability; global SNCA‐knockout mice show p53 accumulation ...
Ziwei Wang, Yoichi Takami, Cheng Wang, Yoshitaka Kase, Hiroshi Koriyama, Jittoku Ihara, Yu Guo, Weidong Liu, Nanxiang Yin, Lisha Yi, Daisuke Nawa, Hikari Takeshita, Shuko Takeda, Akitoshi Hara, Toshimasa Takahashi, Munehisa Shimamura, Hironori Nakagami, Yasufumi Kaneda, Koichi Yamamoto   +18 more
wiley   +1 more source

Grain-sized moxibustion attenuates renal dysfunction and inflammation in naturally aging micethe phosphatidylinositol 3-kinase/protein kinase B/nuclear factor-κB pathway. [PDF]

J Tradit Chin Med
Hui XU, Li QI, Yutong Q, Chang L, Zhenchen LI, Qi M, Shimin L, Danli J, Chen Z.   +8 more
europepmc   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source