Results 171 to 180 of about 7,394,141 (337)
Expression of p16 protein in breast cancer
Breast cancer is the most common cancer and a leading cause of death in women in Saudi Arabia. P16 is a tumour suppressor gene that plays a crucial role in regulating cell cycle.
Saad Samargandy +3 more
core +1 more source
Proteostasis in the regulation of pancreatic islet cell plasticity
Journal of Diabetes Investigation, EarlyView.Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley +1 more source
Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
Biological Biomarkers in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta‐Analysis
Oral Diseases, EarlyView.ABSTRACT Objective To synthesise biological biomarker evidence in proliferative verrucous leukoplakia/proliferative leukoplakia and quantify malignant transformation using eligible longitudinal evidence. Methods Primary human biomarker studies and longitudinal studies reporting extractable malignant‐transformation events and denominators were ...
Madawi Faisal Alkeheli, Hisham I. Othman
wiley +1 more source
Methylation of E-cadherin and hMLH1 genes in Indian sporadic breast carcinomas
, 2006 Hypermethylation of promoter regions leading to inactivation of tumor suppressor genes is a common event in the progression of several tumor types. We have employed a novel restriction digestion based multiplex PCR assay to analyse the methylation status
Shanmugam, G. +4 more
core +1 more source
European Journal of Histochemistry, 2009 p16INK4a and p53 are tumor-suppressor genes frequently altered in various malignancies, including cutaneous melanoma. The purpose of the study was to establish the prognostic value of immunohistochemical expression of p16INK4a and p53 in sporadic ...
P Sirigu +8 more
doaj
Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil—A Literature Review
Oral Diseases, EarlyView.ABSTRACT Background Recurrent aphthous stomatitis (RAS) is a common yet therapeutically challenging chronic inflammatory disease of the oral mucosa, characterized by recurrent, painful ulcerations that substantially affect patients' quality of life. Objective This review summarizes current evidence on phytotherapy in RAS, with particular focus on the ...
Ruzica Ivkovic +4 more
wiley +1 more source